Quantitative susceptibility mapping of the rat brain after traumatic brain injury
Quantitative susceptibility mapping of the rat brain after traumatic brain injury
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DOI：
10.1002/nbm.4438
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发表时间：
2020-11-21
影响因子：
2.9
通讯作者：
Grohn, Olli
中科院分区：
文献类型：
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作者：
Chary, Karthik;Nissi, Mikko J.;Grohn, Olli
由创伤性脑损伤（TBI）后的初始侮辱引起的原发性病变引发了一系列继发性组织损伤，在慢性期也可能进展到相连的脑区域。因此，本研究的目的是研究大鼠严重外侧液体撞击损伤后继发性组织变化的易感性分布变化。我们将定量易感性图谱（QSM）和R-2*测量结果与原发病变外但与病变部位相连的白质和灰质区域的组织学分析进行了比较。我们证明，白质和灰质区域的易感性变化可归因于髓磷脂减少，铁和钙的积累以及胶质瘤。在R-2*图中显示正常的病变部位的吻侧区域，QSM显示继发性损伤引起的定量变化。然而，QSM和R-2*的结合在解开潜在的组织变化（如铁积累、脱髓鞘或钙化）方面提供了信息。因此，将QSM与R-2*测量相结合可以提供更详细的组织变化评估，并可能为改进TBI和其他几种复杂神经退行性疾病的诊断铺平道路。
The primary lesion arising from the initial insult after traumatic brain injury (TBI) triggers a cascade of secondary tissue damage, which may also progress to connected brain areas in the chronic phase. The aim of this study was, therefore, to investigate variations in the susceptibility distribution related to these secondary tissue changes in a rat model after severe lateral fluid percussion injury. We compared quantitative susceptibility mapping (QSM) and R-2* measurements with histological analyses in white and grey matter areas outside the primary lesion but connected to the lesion site. We demonstrate that susceptibility variations in white and grey matter areas could be attributed to reduction in myelin, accumulation of iron and calcium, and gliosis. QSM showed quantitative changes attributed to secondary damage in areas located rostral to the lesion site that appeared normal in R-2* maps. However, combination of QSM and R-2* was informative in disentangling the underlying tissue changes such as iron accumulation, demyelination, or calcifications. Therefore, combining QSM with R-2* measurement can provide a more detailed assessment of tissue changes and may pave the way for improved diagnosis of TBI, and several other complex neurodegenerative diseases.