Tumor pH-responsive metastable-phase manganese sulfide nanotheranostics for traceable hydrogen sulfide gas therapy primed chemodynamic therapy
Tumor pH-responsive metastable-phase manganese sulfide nanotheranostics for traceable hydrogen sulfide gas therapy primed chemodynamic therapy
复制标题
肿瘤 pH 响应亚稳态硫化锰纳米治疗剂用于可追踪硫化氢气体治疗引发的化学动力学治疗
DOI：
10.7150/thno.42981
复制
发表时间：
2020-01-01
期刊：
影响因子：
12.4
通讯作者：
Huang, Peng
中科院分区：
文献类型：
--
作者：
He, Ting;Qin, Xialing;Huang, Peng
锰基纳米材料由于其优异的理化性质，引起了癌症纳米治疗学的极大兴趣。在这里，我们报道了一种尺寸可控、可生物降解和亚稳态γ相硫化锰纳米治疗剂的简便湿化学合成方法，该方法用于肿瘤pH响应型可追踪气体疗法引发的化学动力学疗法（CDT），使用牛血清白蛋白（BSA）作为生物模板（最终产品表示为MnS@ 牛血清白蛋白）。所制备的MnS@BSA可以响应弱酸性肿瘤微环境而降解，释放用于气体治疗的硫化氢（H 2 S）和用于磁共振成像（MRI）和CDT的锰离子。体外实验验证了MnS@ BSA 在pH 6.8 下的pH 响应性，并且在其降解过程中检测到H 2 S 气体和• OH 自由基。体内实验表明，静脉注射MnS@BSA后，可有效启动T 1 加权MRI，显着抑制肿瘤生长并大大延长荷瘤小鼠的生存期。我们的研究结果表明，MnS@ BSA 纳米治疗学在可追踪的 H 2 S 气体疗法引发癌症 CDT 方面具有巨大潜力。
Manganese-based nanomaterials have piqued great interest in cancer nanotheranostics, owing to their excellent physicochemical properties. Here we report a facile wet-chemical synthesis of size-controllable, biodegradable, and metastable γ-phase manganese sulfide nanotheranostics, which is employed for tumor pH-responsive traceable gas therapy primed chemodynamic therapy (CDT), using bovine serum albumin (BSA) as a biological template (The final product was denoted as MnS@ BSA). The as-prepared MnS@ BSA can be degraded in response to the mildly acidic tumor microenvironment, releasing hydrogen sulfide (H 2 S) for gas therapy and manganese ions for magnetic resonance imaging (MRI) and CDT. In vitro experiments validated the pH-responsiveness of MnS@ BSA at pH 6.8 and both H 2 S gas and• OH radicals were detected during its degradation. In vivo experiments showed efficiently tumor turn-on T 1-weighted MRI, significantly suppressed tumor growth and greatly prolonged survival of tumor-bearing mice following intravenous administration of MnS@ BSA. Our findings indicated that MnS@ BSA nanotheranostics hold great potential for traceable H 2 S gas therapy primed CDT of cancer.