EEG correlates of methylphenidate response among children with ADHD: A preliminary report
EEG correlates of methylphenidate response among children with ADHD: A preliminary report
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DOI：
10.1016/s0006-3223(98)00250-9
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发表时间：
1999-06-15
影响因子：
10.6
通讯作者：
Reite, ML
中科院分区：
文献类型：
--
作者：
Loo, SK;Teale, PD;Reite, ML
背景资料：最近的电生理学研究发现，注意力缺陷多动障碍（ADHD）儿童和年龄匹配的对照组之间存在相当一致的差异。本研究探讨脑电图（EEG）的变化与一个双盲，安慰剂对照管理哌甲酯儿童ADHD.Methods：受试者是10名儿童，年龄8至13岁，与ADHD的初步诊断。在基线和认知激活conditions.Results：重复测量方差分析表明，表现出积极的药物反应的儿童有减少的θ和α以及增加的β在额叶区域，而nonresponses显示适当的模式（p <0.05），在额叶，中央和中线区域的7个电极记录脑电活动。提高警惕的任务和变化之间的显着相关性出现在额叶电极的β活动，以及：结论：这些初步研究结果表明，有不同的电生理相关性哌甲酯ADHD儿童谁是药物反应和无反应。(C)1999年生物精神病学学会。
Background: Recent electrophysiologic studies have found fairly consistent differences between children with attention-deficit/hyperactivity disorder (ADHD) and age-matched control subjects. The present study examined electroencephalogram (EEG) changes associated with a double blind, placebo-controlled administration of methylphenidate among children with ADHD.Methods: Subjects were 10 children, ages 8 to 13, with a primary diagnosis of ADHD. Brain electrical activity was recorded with 7 electrodes in the frontal, central, and midline areas during baseline and cognitive activation conditions.Results: Repeated-measures ANOVAs indicate that children exhibiting a positive medication response had reductions of theta and alpha as well as increased beta in the frontal regions, while nonresponders showed the apposite pattern (p < .05). Significant correlations between improvement on a vigilance task and changes in beta activity in the frontal electrodes emerged as well:Conclusions: These preliminary findings indicate that there are different electrophysiologic correlates to methylphenidate among ADHD children who are medication responders and nonresponders. (C) 1999 Society of Biological Psychiatry.