Dietary Acid Load: A Novel Nutritional Target in Overweight/Obese Children with Asthma?
Dietary Acid Load: A Novel Nutritional Target in Overweight/Obese Children with Asthma?
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DOI：
10.3390/nu11092255
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发表时间：
2019-09-01
期刊：
影响因子：
5.9
通讯作者：
Moreira, Pedro
中科院分区：
文献类型：
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作者：
Cunha, Pedro;Paciencia, Ines;Moreira, Pedro
肥胖已被反复与哮喘，并提出了几个潜在的机制，在病因学的肥胖哮喘表型。考虑到肺在全身pH和酸碱调节中起重要作用，是哮喘发生的关键器官，并且几种营养素的营养不足和高膳食酸负荷可影响气道炎症和反应性，我们旨在验证膳食酸负荷可能与儿童哮喘相关的假设。对699名7-12岁儿童（52%为女性）的数据进行了分析。进行人体测量以评估体重指数。膳食酸负荷的计算使用潜在的肾脏酸负荷（PRAL）方程从24小时的饮食回忆管理的儿童。采用残差法计算总能量摄入的调整后PRAL。肺功能和气道可逆性评估肺功能。哮喘定义为过去12个月内支气管扩张阳性或自我报告的医学诊断伴报告症状（喘息、呼吸困难或干咳）。调整能量摄入、性别、年龄、父母教育水平和体力活动后，超重/肥胖儿童中哮喘与PRAL之间存在显著正相关[比值比（OR）= 1.953，95%CI = 1.024，3.730]。我们的研究结果表明，膳食酸负荷可能是超重/肥胖哮喘表型发展的一个可能机制。
Obesity has been repeatedly linked to asthma, and several potential mechanisms have been proposed in the etiologies of the obese-asthma phenotype. Considering that lungs play an important role in systemic pH and acid-base regulation, are a key organ in asthma development, and that nutritional inadequacy of several nutrients and high dietary acid load can affect airway inflammation and reactivity, we aimed to test the hypothesis that dietary acid load may be associated with asthma in children. Data on 699 children (52% females), aged 7-12 years, were analyzed. Anthropometric measurements were performed to assess body mass index. Dietary acid load was calculated using potential renal acid load (PRAL) equations from a 24 h dietary recall administrated to children. Adjusted PRAL for total energy intake was applied with the use of the residual method. Lung function and airway reversibility were assessed with spirometry. Asthma was defined by a positive bronchodilation or self-reported medical diagnosis with reported symptoms (wheezing, dyspnea, or dry cough) in the past 12 months. After adjustment for energy intake, sex, age, parent's education level, and physical activity, positive and significant associations were found between asthma and PRAL [odds ratio (OR) = 1.953, 95% CI = 1.024, 3.730) in overweight/obese children. Our findings suggest that dietary acid load might be a possible mechanism in overweight/obese-asthma phenotype development.