The FAR proteins of parasitic nematodes:: their possible involvement in the pathogenesis of infection and the use of Caenorhabditis elegans as a model system to evaluate their function
The FAR proteins of parasitic nematodes:: their possible involvement in the pathogenesis of infection and the use of Caenorhabditis elegans as a model system to evaluate their function
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DOI：
10.1007/s00430-002-0158-6
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发表时间：
2003-02-01
影响因子：
5.4
通讯作者：
Bradley, JE
中科院分区：
文献类型：
--
作者：
Garofalo, A;Kennedy, MW;Bradley, JE
寄生线虫分泌一类结构新颖的脂肪酸和视黄醇结合（FAR）蛋白到宿主的周围组织中。这些蛋白质是令人感兴趣的，因为它们可能在清除寄生虫生存所必需的宿主脂肪酸和类维生素A中起重要作用，还因为这些脂质的局部消耗可能具有损害宿主免疫应答的免疫调节作用。FAR蛋白的生物学功能的研究受到与寄生线虫的生命周期繁殖相关的困难和寄生虫目前难以逆转遗传研究的严重阻碍。然而，自由生活的线虫秀丽隐杆线虫的基因组编码八种FAR样蛋白，在这篇综述中，我们比较了秀丽隐杆线虫的FAR蛋白。线虫和寄生线虫，并讨论了C.线虫作为研究寄生线虫FAR蛋白生物学功能的模型系统。
Parasitic nematodes secrete a structurally novel class of fatty acid and retinol-binding (FAR) protein into the surrounding tissues of the host. These proteins are of interest because they may play an important role in scavenging fatty acids and retinoids from the host that are essential for the survival of the parasite and also because the localised depletion of such lipids may have immunomodulatory effects that compromise the host immune response. Research into the biological function(s) of the FAR proteins has been severely hampered by the difficulties associated with the life-cycle propagation of parasitic nematodes and the current intractability of the parasites to reverse-genetic studies. The genome of the free-living nematode Caenorhabditis elegans, however, encodes eight FAR-like proteins, and in this review we compare the FAR proteins of C. elegans and parasitic nematodes, and we discuss the suitability of C. elegans as a model system to investigate the biological function(s) of the FAR proteins of parasitic nematodes.