A new graphic plot analysis for cerebral blood flow and partition coefficient with iodine-123-iodoamphetamine and dynamic SPECT validation studies using oxygen-15-water and PET.
A new graphic plot analysis for cerebral blood flow and partition coefficient with iodine-123-iodoamphetamine and dynamic SPECT validation studies using oxygen-15-water and PET.
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发表时间：
1993-03
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通讯作者：
Takashi Yokoi;Hidehiro Iida;Hiroshi Itoh;Iwao Kanno
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作者：
Takashi Yokoi;Hidehiro Iida;Hiroshi Itoh;Iwao Kanno
为了使用动态测量来估计局部脑血流量（rCBF）和脑血分配系数（lambda），提出了一种新的图形图分析。通过假设示踪动力学的两室模型，我们得出线性关系为 Y(t) = K1 - k2 X(t)，其中 Y(t) 是脑组织活动与时间积分动脉血活动的比率，X(t) 是时间积分脑组织活动与时间积分动脉血活动的比率。 Y(t) 对 X(t) 的绘图产生一条直线，回归线的 y 和 x 截距分别代表 rCBF (K1) 和 lambda。斜率是冲刷常数 (-k2)。该方法适用于 14 名使用 N-异丙基-p-碘-123 碘苯丙胺 ([123I]IMP) 的受试者。正常受试者灰质中 K1 和 lambda 的平均值分别为 41.3 +/- 6.7 ml/100 g/min 和 29.6 +/- 6.5 ml/g。使用 H2(15)O 放射自显影方法与正电子发射断层扫描 (PET) 进行的比较研究表明，IMP K1 和 PET rCBF 之间具有良好的相关性 [r = 0.822； K1 = 0.842 rCBF + 0.030（毫升/克/分钟）]。使用图形方法得到的 K1 值与使用非线性最小二乘拟合技术得到的值非常一致（K1 的 r = 0.992；lambda 的 r = 0.941）。当扫描时间改变时，图形方法中估计的 K1 值没有改变。我们得出的结论是，在 60 分钟的扫描时间内，两室模型对于 IMP 动力学是可接受的。当应用于动态数据时，图形方法可以可靠且快速地估计 rCBF。
To estimate regional cerebral blood flow (rCBF) and brain-blood partition coefficient (lambda) using a dynamic measurement, a new graphic plot analysis is proposed. By assuming a two-compartment model for tracer kinetics, we derived the linear relationship as Y(t) = K1 - k2 X(t), where Y(t) is the ratio of brain tissue activity-to-time-integrated arterial blood activity and X(t) is the ratio of time-integrated brain tissue activity-to-time-integrated arterial blood activity. A plot of Y(t) against X(t) yields a straight line and the y- and x-intercept of the regression line represent rCBF (K1) and lambda, respectively. The slope is a washout constant (-k2). This method was applied to 14 subjects with N-isopropyl-p-iodine-123 iodoamphetamine ([123I]IMP). The mean values of K1 and lambda for normal subjects were 41.3 +/- 6.7 ml/100 g/min and 29.6 +/- 6.5 ml/g, respectively, in the gray matter. A comparative study with positron emission tomography (PET) using an H2(15)O autoradiographic method revealed good correlation between IMP K1 and PET rCBF [r = 0.822; K1 = 0.842 rCBF + 0.030 (ml/g/min)]. The values of K1 using the graphical method were in excellent agreement with those using a nonlinear least-squares fitting technique (r = 0.992 for K1; r = 0.941 for lambda). The estimated K1 values in the graphical method were not changed when scanning times were varied. We conclude that a two-compartment model is acceptable for IMP kinetics within a scan time of 60 min. The graphical method gives a reliable and rapid estimation of rCBF when applied to dynamic data.