HUMAN IMMUNODEFICIENCY VIRUS-INFECTION IN HETEROSEXUAL INTRAVENOUS-DRUG-USERS IN SAN-FRANCISCO
HUMAN IMMUNODEFICIENCY VIRUS-INFECTION IN HETEROSEXUAL INTRAVENOUS-DRUG-USERS IN SAN-FRANCISCO
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DOI：
10.2105/ajph.77.2.169
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发表时间：
1987-02-01
影响因子：
12.7
通讯作者：
CARLSON, JR
中科院分区：
文献类型：
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作者：
CHAISSON, RE;MOSS, AR;CARLSON, JR
为了调查旧金山弗朗西斯科感染人类免疫缺陷病毒（HIV）的风险，确定了从社区招募的281名异性恋静脉注射吸毒者的HIV抗体流行率。10%的受试者具有ELISA和Western印迹证实的抗体血清阳性（95%CI 6.8- 14.2%）。对行为因素的分析显示，在注射时经常共用针头的成瘾者中，特别是与两个或两个以上的人共用针头的成瘾者血清阳性的风险增加（比值比+5.43; 95%CI 1.08-52.5）。黑人和拉丁美洲人也比白人有更高的血清阳性率，并且在调整共用针头后，这一发现仍然存在（调整后的比值比= 2.8; 95%CI 0.84 -8.59）。血清阳性与年龄、性别、吸毒时间或卖淫史无关。这些数据表明，一种新的艾滋病（获得性免疫缺陷综合症）在静脉注射毒品使用者中的流行，类似于弗朗西斯科同性恋者中发生的情况，是可能的。1985年血清阳性率相对较低，这为卫生官员提供了一个重要的机会，可以进行干预，并试图防止吸毒者普遍感染艾滋病毒。
To investigate the risk of infection with the human immunodeficiency virus (HIV) in San Francisco, the prevalence of antibodies to HIV was determined in 281 heterosexual intravenous drug users recruited from community-based settings. Ten percent of subjects had ELISA and Western blot confirmed seropositivity for antibodies (95 percent CI 6.8-14.2 percent). Analysis of behavioral factors revealed an increased risk of seropositivity in addicts who reported regularly sharing needles when injecting, particularly those sharing with two or more persons (odds ratio + 5.43; 95 percent CI 1.08-52.5). Blacks and Latinos also had a greater prevalence of seropositivity than Whites, and this finding persisted after adjustment for needle sharing (adjusted odds ratio = 2.8; 95 percent CI .84-8.59). Seropositivity was not associated with age, sex, duration of drug use, or history of prostitution. These data indicate that a new epidemic of AIDS (acquired immunodeficiency syndrome) in intravenous drug users, similar to that which has occurred among homosexuals in San Francisco, is possible. The relatively low seroprevalence in 1985 provides health officials an important opportunity to intervene and attempt to prevent widespread infection of drug users with HIV.