Organogenesis of the Caenorhabditis elegans intestine
Organogenesis of the Caenorhabditis elegans intestine
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DOI：
10.1006/dbio.1999.9471
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发表时间：
1999-12-01
影响因子：
2.7
通讯作者：
Priess, JR
中科院分区：
文献类型：
--
作者：
Leung, B;Hermann, GJ;Priess, JR
秀丽隐杆线虫的肠道是一个仅由20个细胞组成的上皮管，由一个称为E的单个胚胎卵裂球克隆发育而来。我们描述了塑造肠道的细胞事件。这些事件包括肠道原基中细胞的细胞质极化、特定细胞组的插入、原基内细胞外腔的产生以及黏着连接的形成。肠道原基的极化与不对称微管细胞骨架的产生有关，并且微管功能在后续的细胞极性中起作用。我们表明，一个分离的E卵裂球能够产生极化的肠道细胞，这表明肠道器官发生中的一些主要事件不依赖于与周围组织的相互作用。我们将肠道器官发生与第二个上皮器官——咽的发育的一些基本步骤进行比较和对比，并提出这些差异如何导致具有不同形状的器官。（C）1999年学术出版社。
The intestine of Caenorhabditis elegans is an epithelial tube consisting of only 20 cells and is derived clonally from a single embryonic blastomere called E. We describe the cellular events that shape the intestine. These events include cytoplasmic polarization of cells in the intestinal primordium, the intercalation of specific sets of cells, the generation of an extracellular cavity within the primordium, and adherens junction formation. The polarization of the intestinal primordium is associated with the generation of an asymmetric microtubule cytoskeleton, and microtubule function plays a role in subsequent cell polarity. We show that an isolated E blastomere is capable of generating polarized intestinal cells, indicating that some of the major events in intestinal organogenesis do not depend upon interactions with surrounding tissues. We compare and contrast intestinal organogenesis with some of the basic steps in development of a second epithelial organ, the pharynx, and suggest how these differences lead to organs with distinct shapes. (C) 1999 Academic Press.