Cytotoxic Tetraprenylated Alkaloids from the South China Sea Gorgonian Euplexaura robusta
Cytotoxic Tetraprenylated Alkaloids from the South China Sea Gorgonian Euplexaura robusta
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南海柳珊瑚的细胞毒性四异戊二烯化生物碱
DOI：
10.1002/cbdv.201100374
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发表时间：
2012-10-01
影响因子：
2.9
通讯作者：
Li, Guo-Qiang
中科院分区：
文献类型：
--
作者：
Zhang, Jin-Rong;Li, Ping-Lin;Li, Guo-Qiang
从中国广西省涠洲岛采集的柳珊瑚中分离出九种非手性四异戊二烯化生物碱，包括三种新化合物，分别命名为 malonganenones IK (13, resp.)，以及六种已知类似物 49。通过广泛的光谱分析，特别是其 1D 和 2D NMR 数据，阐明了化合物 13 的结构。化合物1、4、6和7对K562和HeLa肿瘤细胞系表现出中等的细胞毒性，IC50值范围为0.35至10.82μM。化合物6在浓度为10μM时对c-Met激酶也表现出中等的抑制活性。
Nine achiral tetraprenylated alkaloids, including three new compounds, named malonganenones IK (13, resp.), together with six known analogs, 49, were isolated from the gorgonian Euplexaura robusta collected from Weizhou Island of Guangxi Province, China. The structures of compounds 13 were elucidated by extensive spectral analyses, especially of their 1D- and 2D-NMR data. Compounds 1, 4, 6, and 7 showed moderate cytotoxicities against K562 and HeLa tumor cell lines with IC50 values ranging from 0.35 to 10.82 mu M. Compound 6 also showed moderate inhibitory activity against c-Met kinase at a concentration of 10 mu M.