Gold nanoparticle targeted photoacoustic cavitation for potential deep tissue imaging and therapy.
Gold nanoparticle targeted photoacoustic cavitation for potential deep tissue imaging and therapy.
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DOI：
10.1364/boe.4.000066
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发表时间：
2013-01-01
影响因子：
3.4
通讯作者：
Murray TW
中科院分区：
文献类型：
--
作者：
Ju H;Roy RA;Murray TW
激光产生等离子体纳米颗粒周围的蒸汽气泡可以通过应用超声场来增强;这是一种被称为光声空化的技术。光和超声的组合允许在比单独使用任一模态可以实现的更低的激光能量密度和峰值负超声压力下形成气泡。这些气泡的生长和塌陷导致局部机械破坏和声发射，并且可以潜在地用于诱导和监测组织治疗。光声空化研究了广泛的超声压力和纳米粒子浓度的金纳米棒和纳米球。两种纳米颗粒类型的空化阈值注量被发现在超声场的存在下急剧减少。结果表明，光声空化可以潜在地在生物组织中的深度处产生，而不超过组织表面处的超声或激光辐射的安全极限。
The laser generation of vapor bubbles around plasmonic nanoparticles can be enhanced through the application of an ultrasound field; a technique referred to as photoacoustic cavitation. The combination of light and ultrasound allows for bubble formation at lower laser fluence and peak negative ultrasound pressure than can be achieved using either modality alone. The growth and collapse of these bubbles leads to local mechanical disruption and acoustic emission, and can potentially be used to induce and monitor tissue therapy. Photoacoustic cavitation is investigated for a broad range of ultrasound pressures and nanoparticle concentrations for gold nanorods and nanospheres. The cavitation threshold fluences for both nanoparticle types are found to drastically reduce in the presence of an ultrasound field. The results indicate that photoacoustic cavitation can potentially be produced at depth in biological tissue without exceeding the safety limits for ultrasound or laser radiation at the tissue surface.