CAN B-CELLS TURN ON VIRGIN T-CELLS
CAN B-CELLS TURN ON VIRGIN T-CELLS
复制标题
DOI：
10.1038/334253a0
复制
发表时间：
1988-07-21
期刊：
影响因子：
64.8
通讯作者：
MATZINGER, P
中科院分区：
文献类型：
--
作者：
LASSILA, O;VAINIO, O;MATZINGER, P
免疫应答启动的第一个事件是捕获抗原并将其呈递给T细胞。这种呈递涉及两个不同的步骤：（1）抗原的展示，其需要与呈递细胞表面上的MHC分子结合的抗原的摄取、加工和再表达;和（2）触发，其中呈递细胞提供导致应答T细胞活化的信号。有两种细胞可以捕获抗原，一种是“专职”抗原呈递细胞（APC），如树突状细胞和巨噬细胞，另一种是B细胞。这两种类型的细胞都可以展示抗原，并且已知APC能够触发静息T细胞。但是，尽管有体外证据表明某些B细胞类型可以重新激活先前激活的T细胞1 -6，但尚不清楚B细胞是否可以通过提供激活静息T细胞所需的信号来启动免疫应答。我们推断，静息状态的B细胞不应该具有这种能力，因为这会给自身独特型的耐受性带来问题。通过利用禽类造血系统的独特性质，我们已经检查了体内B细胞的呈递能力，并且发现静息B细胞确实不能激活静息T细胞。
The first event in the initiation of an immune response is the capture and presentation of antigen to T cells. Such presentation involves two distinct steps: (1) display of the antigen, which requires uptake, processing and re-expression of the antigen in association with MHC molecules on the presenting cell surface; and (2) triggering, in which the presenting cell provides signals leading to the activation of the responding T cell. Two sorts of cells can capture antigens, the 'professional' antigen-presenting cells (APCs) such as dendritic cells and macrophages, and the B cells. Both types of cells can display antigens and the APCs are known to be able to trigger resting T cells. But despitein vitroevidence that certain B-cell types can reactivate previously-activated T cells1–6, it is not yet clear whether a B cell can initiate an immune response by providing the signals necessary to activate a resting T cell. We reasoned that resting B cells should not have this capacity because of the problems this would present with tolerance to self idiotypes. By exploiting the unique properties of the avian haematopoietic system, we have examined the presenting capacity of B cellsin vivoand found that resting B cells are indeed unable to activate resting T cells.