SUBCELLULAR-LOCALIZATION OF 2 LONG-CHAIN ACYL-COENZYME-A SYNTHETASES IN CANDIDA-LIPOLYTICA
SUBCELLULAR-LOCALIZATION OF 2 LONG-CHAIN ACYL-COENZYME-A SYNTHETASES IN CANDIDA-LIPOLYTICA
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DOI：
10.1111/j.1432-1033.1978.tb12533.x
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发表时间：
1978-01-01
期刊：
影响因子：
--
通讯作者：
NUMA, S
中科院分区：
文献类型：
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作者：
MISHINA, M;KAMIRYO, T;NUMA, S
本文研究了两种长链酰基辅酶A合成酶、甘油磷酸酰基转移酶和酰基辅酶A氧化系统的亚细胞定位。在油酸上生长的解脂植物。酰基辅酶A合成酶I分布在不同的亚细胞组分中，包括甘油磷酸酰基转移酶所在的微粒体和线粒体。酰基辅酶A合成酶II位于酰基辅酶A氧化系统所在的微体中。这些结果支持先前的结论，即酰基辅酶A合成酶I负责产生用于合成细胞脂质的酰基辅酶A，而酰基辅酶A合成酶II提供仅通过β-CoA降解的酰基辅酶A。氧化
Studies were made on the subcellular localization of 2 long-chain acyl-coenzyme-A synthetases as well as glycerolphosphate acyltransferase and the acyl-CoA-oxidizing system in C. lipolytica grown on oleic acid. Acyl-CoA synthetase I is distributed among different subcellular fractions, including microsomes and mitochondria where glycerolphosphate acyltransferase is located. Acyl-CoA synthetase II is localized in microbodies where the acyl-CoA-oxidizing system is located. These results support the previous conclusion that acyl-CoA synthetase I is responsible for the production of acyl-CoA to be utilized for the synthesis of cellular lipids, while acyl-CoA synthetase II provides acyl-CoA that is exclusively degraded via .beta.-oxidation.