Transcription factors as therapeutic targets in CNS disorders.
Transcription factors as therapeutic targets in CNS disorders.
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DOI：
10.2174/157488909789104820
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
M. Kane;B. Citron
中科院分区：
文献类型：
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作者：
M. Kane;B. Citron
影响中枢神经系统的疾病通常涉及程序性神经元损失。在神经退行性疾病、创伤性和缺血性损伤中发生的基因表达的变化已经得到证实。然而，我们目前缺乏足够的知识的潜在机制，导致改变基因表达谱影响细胞存活的大脑和脊髓。通过改变促细胞凋亡和抗细胞凋亡转录因子的平衡，诱导促细胞死亡基因表达谱加速细胞损失。这些转录因子的失调构成了这些疾病中最早的事件之一，并且可以在不可逆的神经元死亡之前的一个狭窄的时间段内提供干预的治疗机会窗口。人们对调节这些细胞死亡因子以防止或减轻对神经元的损伤越来越感兴趣，目的是改善受影响个体的生活。在这里，我们回顾了一些最近的专利，在这项研究的过程中，在五个不同的转录因子的背景下开发。
Disorders affecting the central nervous system frequently involve programmed neuronal loss. There are well-established changes in gene expression that occur in neurodegenerative diseases, and traumatic and ischemic injuries. Yet, we currently lack sufficient knowledge of the underlying mechanisms leading to the altered gene expression profiles affecting cell survival in the brain and spinal cord. The cell loss is accelerated by the induction of pro-cell death gene expression profiles through an altered balance of pro- and anti-apoptotic transcription factors. Dysregulation of these transcription factors constitutes one of the earliest events in these disorders and may offer a therapeutic window of opportunity for intervention across a narrow time period prior to irreversible neuronal death. There has been increasing interest in the modulation of these cell death factors to prevent or mitigate damage to neurons, with the goal of improving the lives of affected individuals. Here we review some of the recent patents that have been developed in the course of this research in the context of five different transcription factors.