CLASSICAL-CONDITIONING, DECAY AND EXTINCTION OF COCAINE-INDUCED HYPERACTIVITY AND STEREOTYPY
CLASSICAL-CONDITIONING, DECAY AND EXTINCTION OF COCAINE-INDUCED HYPERACTIVITY AND STEREOTYPY
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DOI：
10.1016/0024-3205(83)90817-2
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发表时间：
1983-01-01
期刊：
影响因子：
6.1
通讯作者：
BRIDGER, WH
中科院分区：
文献类型：
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作者：
BARR, GA;SHARPLESS, NS;BRIDGER, WH
在每天10次多次条件刺激与注射可卡因（15 mg/kg）配对后，单独呈现刺激引起大鼠类似于可卡因诱导的行为。这些行为包括直立、嗅闻、摇头和水平运动活动（交叉）的持续时间或频率增加。其中几种行为的条件反应水平接近药物本身诱导的水平。条件药物效应在15天内显示衰减，但在4天的每日试验期间几乎没有消退。多巴胺代谢产物，高香草酸和二羟基苯乙酸，脑浓度在条件和pseudoconditioned控制组在尾状核和中脑边缘区相似。行为学结果表明，在经典条件反射范式中，先前中性刺激可以引起类似于可卡因诱导的行为，并且某些条件反射表现出与时间相关的下降。这与所报道的安非他明的行为效应的条件反射相一致，但在对大脑多巴胺周转的作用方面有所不同。
Following 10 daily pairings of multiple conditioned stimuli with injection of cocaine (15 mg/kg), the presentation of the stimuli alone elicited behaviors in rats similar to those induced by cocaine. The behaviors included increased duration or frequency of rearing, sniffing, head bobbing and horizontal locomotor activity (crossing). The level of the conditioned response for several of these behaviors approximated that induced by the drug itself. The conditioned drug effect showed decay over 15 days but little extinction during 4 daily trials. Brain concentrations of the dopamine metabolites, homovanillic acid and dihydroxyphenylacetic acid, were similar in the conditioned and pseudoconditioned control groups in both the caudate and mesolimbic areas. The behavioral results demonstrate that in a classical conditioning paradigm previously neutral stimuli can elicit behaviors similar to those induced by cocaine and that certain conditioned responses show time related decline. This agrees with the reported conditioning of amphetamine''s behavioral effects but differs in terms of the action on brain dopamine turnover.