Use of the anesthetic combination of tiletamine, zolazepam, ketamine, and xylazine for neutering feral cats.
Use of the anesthetic combination of tiletamine, zolazepam, ketamine, and xylazine for neutering feral cats.
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DOI：
10.2460/javma.2002.220.1491
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发表时间：
2002-05
期刊：
影响因子：
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通讯作者：
L. S. Williams;J. Levy;S. Robertson;A. M. Cistola;L. A. Centonze
中科院分区：
文献类型：
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作者：
L. S. Williams;J. Levy;S. Robertson;A. M. Cistola;L. A. Centonze
目的评价替莱他明、唑拉西潘、氯胺酮和赛拉津(TKX)复合麻醉在大规模绝育诊所野猫麻醉中的应用。设计原创性研究。动物7502只野猫。1996年7月至2000年8月，程序猫被它们的饲养员诱捕进行野猫绝育计划。麻醉组合TKX被注射到猫的肌注中，而它们仍然留在陷阱里。每毫升TKX含有50毫克替莱他明、50毫克唑拉西潘、80毫克氯胺酮和20毫克赛拉津。雌性被兽医阉割，而雄性被兽医或兽医学生阉割。育亨宾0.5 mg，静脉滴注于手术结束。记录了每种药物的剂量、猫的信号以及遇到的任何并发症。对这些数据进行了回顾分析(1996年至1999年)和前瞻性分析(2000年)。结果在5766只有完整剂量记录的猫中，4584只(79.5%)接受了单剂TKX。TKX起始量平均为0.24+/-0.04ml/只，总平均剂量为0.27+/-0.09ml，总死亡率为0.35%(26/7502)只猫，单纯麻醉死亡死亡率为0.23%(17/7502)只猫。结论和临床相关性：在大规模的野猫绝育诊所使用TKX有几个好处。TKX组合价格低廉，提供可预测的结果，可以快速和容易地以小体积给药，并与野猫的低死亡率有关。
OBJECTIVE To evaluate the use of the anesthetic combination tiletamine, zolazepam, ketamine, and xylazine (TKX) for anesthesia of feral cats at large-scale neutering clinics. DESIGN Original study. ANIMALS 7,502 feral cats. PROCEDURE Cats were trapped by their caretakers for a feral cat neutering program from July 1996 to August 2000. The anesthetic combination TKX was injected IM into cats while they remained in their traps. Each milliliter of TKX contained 50 mg of tiletamine, 50 mg of zolazepam, 80 mg of ketamine, and 20 mg of xylazine. Females were spayed by veterinarians, whereas males were castrated by veterinarians or veterinary students. Yohimbine (0.5 mg, IV) was administered at the end of the procedure. Logs were kept of the individual drug doses, signalment of the cats, and any complications encountered. These data were analyzed retrospectively (1996 to 1999) and prospectively (2000). RESULTS Of the 5,766 cats for which dosing records were complete, 4,584 (79.5%) received a single dose of TKX. The mean initial dose of TKX was 0.24 +/- 0.04 ml/cat, and the total mean dose of TKX was 0.27 +/- 0.09 ml. Overall mortality rate was 0.35% (26/7,502) cats, and the death rate attributable solely to potential anesthetic deaths was 0.23% (17/7,502) cats. CONCLUSIONS AND CLINICAL RELEVANCE The use of TKX for large-scale feral cat neutering clinics has several benefits. The TKX combination is inexpensive, provides predictable results, can be administered quickly and easily in a small volume, and is associated with a low mortality rate in feral cats.