A review of applications of metabolomics in cancer.
A review of applications of metabolomics in cancer.
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DOI：
10.3390/metabo3030552
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发表时间：
2013-07-05
期刊：
影响因子：
4.1
通讯作者：
Beger RD
中科院分区：
文献类型：
--
作者：
Beger RD
癌症是一种破坏性的疾病，它会改变细胞的新陈代谢和周围环境。代谢组学是一种不断发展的强大技术，能够检测组织和生物体液中的数百至数千种代谢物。代谢组学技术的最新进展使人们能够更深入地研究癌症的代谢，并更好地了解癌细胞如何利用糖酵解（称为“瓦尔堡效应”）有利地产生肿瘤增殖和血管形成所需的氨基酸、核苷酸和脂质。目前，代谢组学研究正被用于发现临床诊断癌症的生物标志物，以更好地了解其复杂的异质性，发现参与癌症的途径，可用于新的靶点，并在治疗干预期间监测代谢生物标志物。这些代谢组学方法还可以通过向临床医生提供关于癌症患者对医疗干预的反应的有用信息来提供个性化癌症治疗的线索。
Cancer is a devastating disease that alters the metabolism of a cell and the surrounding milieu. Metabolomics is a growing and powerful technology capable of detecting hundreds to thousands of metabolites in tissues and biofluids. The recent advances in metabolomics technologies have enabled a deeper investigation into the metabolism of cancer and a better understanding of how cancer cells use glycolysis, known as the “Warburg effect,” advantageously to produce the amino acids, nucleotides and lipids necessary for tumor proliferation and vascularization. Currently, metabolomics research is being used to discover diagnostic cancer biomarkers in the clinic, to better understand its complex heterogeneous nature, to discover pathways involved in cancer that could be used for new targets and to monitor metabolic biomarkers during therapeutic intervention. These metabolomics approaches may also provide clues to personalized cancer treatments by providing useful information to the clinician about the cancer patient’s response to medical interventions.