Investigation of compacted hydrophilic and hydrophobic colloidal silicon dioxides as glidants for pharmaceutical excipients
Investigation of compacted hydrophilic and hydrophobic colloidal silicon dioxides as glidants for pharmaceutical excipients
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DOI：
10.1016/j.powtec.2004.01.020
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发表时间：
2004-03-18
影响因子：
5.2
通讯作者：
Schmidt, PC
中科院分区：
文献类型：
--
作者：
Jonat, S;Hasenzahl, S;Schmidt, PC
使用微晶纤维素、预胶化淀粉和α-乳糖一水合物作为模型辅料，比较了压实亲水性和疏水性胶体二氧化硅在混合时间和混合器类型方面的助流剂特性。流动性的研究，包括休止角测量和一种新的动态传送带的方法，显示了胶体二氧化硅类型之间的流动增强的差异。混合条件对流动性的影响，也观察到亲水性胶体二氧化硅。这些差异可以通过SEM和XPS研究来解释，表明辅料表面上助流剂颗粒均匀覆盖的重要性。详细描述了胶体二氧化硅颗粒在赋形剂表面的尺寸和分布、混合时间、混合器类型的影响。此外，水分研究表明，胶体二氧化硅可保护辅料免受湿度引起的流动性降低。(C)2004 Elsevier B. V.保留所有权利。
The glidant properties of compacted hydrophilic and hydrophobic colloidal silicon dioxides were compared with respect to mixing time and mixer type using microcrystalline cellulose, pregelatinized starch and a-lactose-monohydrate as model excipients. Flowability studies, including angle of repose measurements and a novel dynamic conveyor belt method, showed differences in the flow enhancement between the colloidal silicon dioxide types. An influence of mixing conditions on flowability was also observed for hydrophilic colloidal silicon dioxide. These differences could be explained by SEM and XPS investigations, indicating the importance of a uniform coverage of the glidant particles on the excipient's surface. The influence of size and distribution of the colloidal silicon dioxide particles on the surface of the excipient, mixing time, mixer type are described in detail. In addition, moisture studies showed that colloidal silicon dioxide protects the excipients against a flowability decrease caused by humidity. (C) 2004 Elsevier B.V. All rights reserved.