Monitoring silver diamine fluoride application with optical coherence tomography.
Monitoring silver diamine fluoride application with optical coherence tomography.
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使用光学相干断层扫描监测氟化二胺银的应用。
DOI：
10.1117/12.2584901
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Fried,D
中科院分区：
文献类型：
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作者：
Abdelaziz,M;Yang,V;Chang,N;Darling,C;Fried,W;Seto,J;Fried,D
本研究的目的是探讨使用光学相干断层扫描 (OCT) 监测氟化二胺银 (SDF) 治疗后龋病病变结构的变化。在牛牙本质块上形成人工龋病灶。每个块被分成5个窗口：一个病变用指甲油覆盖作为对照（LC），一个声音窗口用指甲油覆盖（SC），一个声音窗口暴露于SDF（SCT），一个病变接受2次SDF应用（L2），而另一个病变接受1次SDF应用（L1）。在使用 SDF 之前，使用 OCT 对每个窗口进行扫描，随后每周进行一次扫描，持续 12 周（在初始 SDF 治疗后）。监测参数例如位于样品表面的平均强度和增加的反射率峰的宽度以及180μm深度处的强度。高分辨率显微镜也用于分析选定的样品。测量参数的变化表明使用SDF后牙本质病变发生了显着变化。 OCT 解决了 SDF 应用后的结构变化以及随着时间的推移而发生的变化。高分辨率显微镜图像证实 SDF 渗透到样品中。可以监控此类变化，以确定是否以及何时需要重新应用 SDF。
The objective of this study was to investigate the use of optical coherence tomography (OCT) for monitoring changes in the structure of caries lesions overtime after treatment with silver diamine fluoride (SDF). Artificial caries lesions were formed on dentin bovine blocks. Each block was partitioned into 5 windows: one lesion was covered by nail varnish as control (LC), one sound window was covered with nail varnish (SC), one sound window was exposed to SDF (SCT), one lesion received 2 applications of SDF (L2), while the other lesion received one application of SDF (L1). Each window was scanned using OCT before SDF application, and every week subsequently, for 12 weeks after initial SDF treatment. Parameters such as mean intensity and the width of the peak of increased reflectivity located at the sample surface and the intensity at a depth of 180-μm were monitored. High-resolution microscopy was also used to for the analysis of selected samples. Changes in the parameters measured showed significant changes on dentin lesions after SDF application. OCT resolved structural changes after SDF application as well as changes overtime. High resolution microscopy images confirm penetration of SDF into the samples. Such changes can potentially be monitored to determine if and when re-application of SDF is needed.