Lessons from the Niche for Generation and Expansion of Hematopoietic Stem Cells.
Lessons from the Niche for Generation and Expansion of Hematopoietic Stem Cells.
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DOI：
10.1016/j.ddstr.2009.06.003
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Zon, Leonard I
中科院分区：
文献类型：
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作者：
Bowman, Teresa V;Zon, Leonard I
造血干细胞（HSC）在临床上用于治疗人类血液相关遗传病和白血病，但这种疗法的可用性受到可移植HSC数量有限的限制。先前在体外扩增造血干细胞的策略会导致分化早熟并降低移植效率。可以模拟胎儿和成人微环境控制 HSC 的机制进行体内分析以用于治疗用途。本综述总结了体内 HSC 生态位的最新研究以及这些知识的临床应用，以促进 HSC 的离体扩增和直接从头生成。
Hematopoietic Stem Cells (HSCs) are used clinically to treat human blood-related genetic diseases and leukemias, but the availability of this therapy is constrained by the limiting number of transplantable HSCs. Previous strategies to expand HSCs in vitro resulted in precocious differentiation and reduced transplant efficiency. In vivo analysis of the mechanisms utilized by fetal and adult niches to control HSCs can be mimicked for therapeutic use. This review summarizes the latest research on the in vivo HSC niche and the clinical applications of this knowledge to promote ex vivo expansion and direct de novo generation of HSCs.