A New Vasculitis Activity Score for Predicting Death in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Patients
A New Vasculitis Activity Score for Predicting Death in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Patients
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DOI：
10.1159/000334357
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发表时间：
2012-01-01
影响因子：
4.2
通讯作者：
Okuda, Seiya
中科院分区：
文献类型：
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作者：
Koike, Kiyomi;Fukami, Kei;Okuda, Seiya
背景/目的：髓过氧化物酶-抗中性粒细胞胞浆抗体(MPO-ANCA)阳性的肾脏受累的显微镜下多血管炎患者有进行性的临床病程。在这项研究中，我们比较了日本血管炎活动评分(JVAS)和伯明翰血管炎活动评分(BVAS)在预测MPO-ANCA相关肾损害患者死亡方面的临床实用性。方法：69例肾受累的MPO-ANCA相关性小血管炎患者，男22例，女47例，年龄69.8±8.7岁。我们回顾研究了哪种评分更能预测患者的不良预后。结果：本组病例发病2年内病死率为33%(23/69)。JVAS与BVAS无相关性。单因素Logistic回归分析显示，JVAS的OR值具有统计学意义(OR1.76，95%可信区间CI，1.29~2.41，P
Background/Aims: Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-positive microscopic polyangiitis patients with renal involvement have been shown to have a progressive clinical course. In this study, we compared the clinical utility of the Japanese Vasculitis Activity Score (JVAS) with the Birmingham Vasculitis Activity Score (BVAS) for predicting death in patients with MPO-ANCA-associated renal involvement. Methods: Sixty-nine patients with MPO-ANCA-associated vasculitis with renal involvement (22 males and 47 females, age 69.8 +/- 8.7 years) were enrolled in this study. We retrospectively investigated which score was better for predicting the poor prognosis of patients. Results: The mortality rate of the patients within 2 years after disease onset was 33% (23/69). JVAS was not correlated with BVAS. Univariate logistic regression analysis for death showed that the odds ratio (OR) of JVAS was statistically significant (OR 1.76,95% confidence interval, Cl, 1.29-2.41, p