The associations of uric acid, cardiovascular and all-cause mortality in peritoneal dialysis patients.
The associations of uric acid, cardiovascular and all-cause mortality in peritoneal dialysis patients.
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DOI：
10.1371/journal.pone.0082342
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Wang HY
中科院分区：
文献类型：
--
作者：
Dong J;Han QF;Zhu TY;Ren YP;Chen JH;Zhao HP;Chen MH;Xu R;Wang Y;Hao CM;Zhang R;Zhang XH;Wang M;Tian N;Wang HY
研究在控制公认的心血管（CV）风险因素后，尿酸（UA）是否是腹膜透析（PD）患者心血管（CV）和全因死亡率的独立预测因子。从隶属于腹膜透析结局社会经济状况（SSOP）研究的7个中心共收集了2264例慢性PD患者。在基线时记录所有人口统计学和实验室数据。采用多变量考克斯回归计算CV和全因死亡率的风险比（HR），并对公认的传统和尿毒症相关CV因素进行校正。有（n = 2193）和无（n = 71）UA测量的患者之间的基线特征无显著差异。 校正年龄、性别和中心规模后，UA每增加1 mg/dL，全因死亡率增加（HR为1.05（1.00 ± 1.10）），CV死亡率增加（HR为1.12（1.05 ± 1.20））。校正年龄、性别和中心规模后，UA的最高性别特异性三分位数预测全因死亡率较高，HR为1.23（1.00 <$1.52），CV死亡率较高，HR为1.69（1.21 <$2.38）。UA的预测价值在年龄小于65岁且基线时无CV疾病或糖尿病的患者中更强。在进一步校正尿毒症相关和传统CV风险因素后，UA作为连续变量和分类变量的预后价值减弱或消失。在PD患者中，UA对CV和全因死亡率的预后价值通常较弱，这受到尿毒症相关和传统CV风险因素的混淆。
To investigate whether uric acid (UA) is an independent predictor of cardiovascular (CV) and all-cause mortality in peritoneal dialysis (PD) patients after controlling for recognized CV risk factors. A total of 2264 patients on chronic PD were collected from seven centers affiliated with the Socioeconomic Status on the Outcome of Peritoneal Dialysis (SSOP) Study. All demographic and laboratory data were recorded at baseline. Multivariate Cox regression was used to calculate the hazard ratio (HR) of CV and all-cause mortality with adjustments for recognized traditional and uremia-related CV factors. There were no significant differences in baseline characteristics between patients with (n = 2193) and without (n = 71) UA measured. Each 1 mg/dL of increase in UA was associated with higher all-cause mortality with 1.05(1.00∼1.10) of HR and higher CV mortality with 1.12 (1.05∼1.20) of HR after adjusting for age, gender and center size. The highest gender-specific tertile of UA predicted higher all-cause mortality with 1.23(1.00∼1.52) of HR and higher CV mortality with 1.69 (1.21∼2.38) of HR after adjusting for age, gender and center size. The predictive value of UA was stronger in patients younger than 65 years without CV disease or diabetes at baseline. The prognostic value of UA as both continuous and categorical variable weakened or disappeared after further adjusted for uremia-related and traditional CV risk factors. The prognostic value of UA in CV and all-cause mortality was weak in PD patients generally, which was confounded by uremia-related and traditional CV risk factors.
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影响因子：
19.6
作者：
Khosla, UM;Zharikov, S;Johnson, RJ
通讯作者：
Johnson, RJ
影响因子：
--
作者：
Garg, JP;Chasan-Taber, S;Chertow, GM
通讯作者：
Chertow, GM
影响因子：
4.2
作者：
Kanbay, Mehmet;Yilmaz, Mahmut Ilker;Johnson, Richard J.
通讯作者：
Johnson, Richard J.
影响因子：
15.8
作者：
Palmer SC;Nistor I;Craig JC;Pellegrini F;Messa P;Tonelli M;Covic A;Strippoli GF
通讯作者：
Strippoli GF
DOI：
10.2215/cjn.09420911
发表时间：
2012-04-01
影响因子：
9.8
作者：
Liu, Wan-Chun;Hung, Chi-Chih;Chen, Hung-Chun
通讯作者：
Chen, Hung-Chun