Synthesis of Programmable Reaction-Diffusion Fronts Using DNA Catalyzers
Synthesis of Programmable Reaction-Diffusion Fronts Using DNA Catalyzers
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DOI：
10.1103/physrevlett.114.068301
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发表时间：
2015-02-09
影响因子：
8.6
通讯作者：
Estevez-Torres, Andre
中科院分区：
文献类型：
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作者：
Zadorin, Anton S.;Rondelez, Yannick;Estevez-Torres, Andre
我们介绍了一种基于DNA的反应-扩散(RD)系统，在该系统中，反应和扩散项可以精确和独立地控制。单个反应组分的有效扩散系数，就像我们在行波上演示的那样，使用自组装的流体动力阻力可以减少2.7倍。这种研发系统的内在可编程性使我们第一次能够设计出能够以最小的相互作用进行反向繁殖的正交自催化剂。我们的结果与Fisher-Kolmogorov-Petrovskii-Piscunov模型的预测在数量上是非常一致的。这些进展为纯化学RD系统花样形成的合理工程开辟了道路。
We introduce a DNA-based reaction-diffusion (RD) system in which reaction and diffusion terms can be precisely and independently controlled. The effective diffusion coefficient of an individual reaction component, as we demonstrate on a traveling wave, can be reduced up to 2.7-fold using a self-assembled hydrodynamic drag. The intrinsic programmability of this RD system allows us to engineer, for the first time, orthogonal autocatalysts that counterpropagate with minimal interaction. Our results are in excellent quantitative agreement with predictions of the Fisher-Kolmogorov-Petrovskii-Piscunov model. These advances open the way for the rational engineering of pattern formation in pure chemical RD systems.