Updating Normal Organ Weights Using a Large Current Sample Database
Updating Normal Organ Weights Using a Large Current Sample Database
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DOI：
10.5858/arpa.2021-0287-oa
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发表时间：
2022-12-01
影响因子：
4.6
通讯作者：
Hooper, Jody E.
中科院分区：
文献类型：
--
作者：
Bell, Michael D.;Long, Thomas;Hooper, Jody E.
背景。-器官重量是尸检分析的重要组成部分。偏离正常器官重量为疾病过程提供了重要线索。正常器官重量的评估依赖于可靠的参考表，但最广泛使用的参考表是基于几十年前的数据或来自相对较小的样本量。客观。-基于当代来源和大样本量，提供器官重量的更新参考表。设计。-器官重量来自4197例经过仔细筛选的成人尸检，这些尸检是在佛罗里达西棕榈滩的棕榈海滩县医学检查办公室和明尼苏达州罗切斯特的马约诊所医院进行的。结果。-本研究中的身高和体重数据反映了这两个变量的公认增加，但最特别的是体重，在过去几十年中观察到。研究数据显示心脏、肝脏和脾脏的器官重量与体重之间存在强正相关性。体重与肺和肾的重量之间存在类似但较弱的关联。脑重量与体重无关，但与年龄呈强烈的负相关。即使在控制体重的情况下，男性的器官也更重，但肝脏的重量除外，男性和女性的肝脏重量相当。这些关联与以前的研究结果一致。目前的研究表明，与现有的参考文献相比，对于一些通常称重的器官，中位器官重量有所增加。结论。这里提出的表格提供了一个更新的参考，应该证明有用的法医和医院设置的尸检病理学家。
Context.-Organ weights are an essential part of autopsy analysis. Deviations from normal organ weights provide important clues to disease processes. The assessment of normal organ weights depends on reliable reference tables, but most widely available reference tables are based on data that are either decades old or derived from relatively small sample sizes. Objective.-To provide an updated reference table of organ weights based on contemporary sources and a large sample size. Design.-Organ weights from 4197 carefully screened autopsies performed on adults at the Palm Beach County Medical Examiner's Office in West Palm Beach, Florida, and the Mayo Clinic Hospital in Rochester, Minnesota. Results.-Height and body weight data in this study reflect the well-recognized increases in both variables, but most particularly in body weight, seen during the last decades. The study data show a strong positive association between organ weight and body weight for the heart, liver, and spleen. There is a similar but weaker association between body weight and the weight of the lungs and kidneys. Brain weight is independent of body weight but shows a strong negative association with age. Even when controlling for body weight, men's organs are heavier, except for the weight of the liver, which is comparable in men and women. These associations are in agreement with the findings of previous studies. The current study suggests that, for some of the commonly weighed organs, there has been an increase in median organ weight when compared with existing references. Conclusions.-The tables presented here provide an updated reference that should prove useful to autopsy pathologists in the forensic and hospital settings.