Mechanisms of Protein Retention in the Golgi
Mechanisms of Protein Retention in the Golgi
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DOI：
10.1101/cshperspect.a005264
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发表时间：
2011-08-01
影响因子：
7.2
通讯作者：
Banfield, David K.
中科院分区：
文献类型：
--
作者：
Banfield, David K.
高尔基体的蛋白质组成与其结构和功能密切相关。由于高尔基体是分泌途径的主要蛋白质分选中心，它面临着在瞬态货物蛋白不断流入和流出的情况下维持其蛋白质组成的独特挑战。我们对蛋白质如何在高尔基体中保留的理解大部分来自对糖基化酶的研究，主要是因为这些蛋白质显示的室特异性分布。从这些和其他对高尔基膜蛋白的研究中，我们现在了解到多种保留机制被采用，其中大多数涉及逆行和顺行转运的迭代动态过程。这种机制依赖于蛋白质构象和基于氨基酸的分选信号，以及跨膜结构域的性质及其与高尔基体独特的脂质组成的关系。
The protein composition of the Golgi is intimately linked to its structure and function. As the Golgi serves as the major protein-sorting hub for the secretory pathway, it faces the unique challenge of maintaining its protein composition in the face of constant influx and efflux of transient cargo proteins. Much of our understanding of how proteins are retained in the Golgi has come from studies on glycosylation enzymes, largely because of the compartment-specific distributions these proteins display. From these and other studies of Golgi membrane proteins, we now understand that a variety of retention mechanisms are employed, the majority of which involve the dynamic process of iterative rounds of retrograde and anterograde transport. Such mechanisms rely on protein conformation and amino acid-based sorting signals as well as on properties of transmembrane domains and their relationship with the unique lipid composition of the Golgi.