Developing effective therapeutics for Alzheimer's disease -- emerging mechanisms and actions in translational medicine.
Developing effective therapeutics for Alzheimer's disease -- emerging mechanisms and actions in translational medicine.
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作者：
C. Zhang
阿尔茨海默病（Alzheimer's disease，AD）是一种不可逆的进行性神经退行性疾病。目前还没有有效的疾病修饰疗法。虽然特定基因的突变已被证明与遗传性早发型AD有关，但该疾病更典型的晚发型的原因仍有待阐明。近年来，对AD病理学特征的研究发现，Aβ在AD发病机制中的重要作用与tau蛋白和神经炎症有关。此外，AD的可改变的风险因素已被确定和表征。值得注意的是，了解AD的潜在机制使得有可能开始开发新的和潜在有效的治疗方法。本文综述了AD转化医学中的一些新机制和方法。
Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder. Presently there are no effective disease-modifying therapies. Although mutations in specific genes have been shown to be linked to inherited early onset form of AD, the causes of the more typical late onset form of the disease remain to be elucidated. Recently, significant effort focused on characterization of the pathology of AD has uncovered emerging mechanisms highlighting the substantial role of Aβ in disease pathogenesis, which is linked to tau pathology and neuro-inflammation. Additionally, modifiable risk factors of AD have been identified and characterized. Notably, understanding the underlying mechanisms of AD made it possible to begin the development of new and potentially effective therapeutics. This review discusses some of these emerging mechanisms and approaches in the translational medicine of AD.