Leg muscle strength is reduced in Parkinson's disease and relates to the ability to rise from a chair
Leg muscle strength is reduced in Parkinson's disease and relates to the ability to rise from a chair
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DOI：
10.1002/mds.10299
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发表时间：
2003-02-01
影响因子：
8.6
通讯作者：
Stoessl, AJ
中科院分区：
文献类型：
--
作者：
Inkster, LM;Eng, JJ;Stoessl, AJ
帕金森病（PD）患者从椅子上站起来有困难;然而，导致这种能力的因素从未被调查过。我们比较了PD患者和健康对照者的下肢力量，并量化了力量和从椅子上站起来的能力之间的关系。10名轻度PD男性和10名性别和年龄匹配的对照组在等速测力计上进行最大同心，等速膝关节和髋关节伸肌扭矩，以量化肌肉力量。受试者也从椅子上在他们舒适的步伐，没有使用他们的手臂和这个任务的持续时间提供了一个衡量坐站（STS）的能力。PD受试者在不同日期在服药和停药状态下接受检测。平均髋关节和膝关节伸肌扭矩较低的受试者与PD，更大的赤字发现在髋关节。在PD受试者中，更大的髋关节力量与更好的STS能力相关，而在对照组中，更大的膝关节力量与更好的STS能力相关。这些结果表明，与对照组相比，患有轻度PD的个体产生较小的肢体力量。力量降低，特别是在臀部，可能是导致PD患者难以从椅子上站起来的一个因素。(C)2002运动障碍协会。
Individuals with Parkinson's disease (PD) have difficulties rising from a chair; however, factors contributing to this inability have never been investigated. We compared lower extremity strength between individuals with PD and healthy controls and quantified the relationships between strength and the ability to rise from a chair. Ten men with mild PD and 10 sex- and age-matched controls performed maximal concentric, isokinetic knee and hip extensor torque on an isokinetic dynamometer to quantify muscle strength. Subjects also rose from a chair at their comfortable pace without the use of their arms and the duration of this task provided a measure of sit-to-stand (STS) ability. Subjects with PD were tested in an on- and off-medication state on different days. Mean hip and knee extensor torques were lower in subjects with PD, with greater deficits found at the hip. Greater hip strength was related to better STS ability in subjects with PD while greater knee strength was related to better STS ability in controls. These results show that individuals with mild PD generate smaller extremity forces compared to controls. Reduced strength, particularly at the hip, may be one factor that contributes to the difficulty of persons with PD to rise from a chair. (C) 2002 Movement Disorder Society.