β-Cell regeneration through the transdifferentiation of pancreatic cells: Pancreatic progenitor cells in the pancreas.
β-Cell regeneration through the transdifferentiation of pancreatic cells: Pancreatic progenitor cells in the pancreas.
复制标题
DOI：
10.1111/jdi.12475
复制
发表时间：
2016-05
影响因子：
3.2
通讯作者：
Lee MK
中科院分区：
文献类型：
--
作者：
Kim HS;Lee MK
胰腺祖细胞的研究一直是人们关注的焦点，因为这些细胞有可能取代胰腺β细胞，用于治疗胰腺β细胞缺失或减少的1型和2型糖尿病患者。在过去的几十年里，通过移植整个胰腺或分离胰岛成功治疗糖尿病的方法几乎已经实现。然而，需要新的胰岛或产生胰岛素的细胞来源来提供足够数量的供体组织。为了克服这一限制，胰腺祖细胞的使用越来越受到关注。特别是胰腺外分泌细胞，如导管上皮细胞和腺泡细胞，由于其分化潜力和胰腺谱系特征，是β细胞再生的有吸引力的候选者。据推测，胰脏祖细胞的β细胞新生可能发生在出生后的胰管中。几项研究表明，胰岛素生成细胞可以出现在成人胰腺的导管组织中。腺泡细胞也可能有分化为产生胰岛素的细胞的潜力。本文综述了近年来胰腺外分泌细胞向胰岛素生成细胞，特别是胰腺导管细胞和胰腺腺泡细胞转分化的研究进展。
Pancreatic progenitor cell research has been in the spotlight, as these cells have the potential to replace pancreatic β‐cells for the treatment of type 1 and 2 diabetic patients with the absence or reduction of pancreatic β‐cells. During the past few decades, the successful treatment of diabetes through transplantation of the whole pancreas or isolated islets has nearly been achieved. However, novel sources of pancreatic islets or insulin‐producing cells are required to provide sufficient amounts of donor tissues. To overcome this limitation, the use of pancreatic progenitor cells is gaining more attention. In particular, pancreatic exocrine cells, such as duct epithelial cells and acinar cells, are attractive candidates for β‐cell regeneration because of their differentiation potential and pancreatic lineage characteristics. It has been assumed that β‐cell neogenesis from pancreatic progenitor cells could occur in pancreatic ducts in the postnatal stage. Several studies have shown that insulin‐producing cells can arise in the duct tissue of the adult pancreas. Acinar cells also might have the potential to differentiate into insulin‐producing cells. The present review summarizes recent progress in research on the transdifferentiation of pancreatic exocrine cells into insulin‐producing cells, especially duct and acinar cells.