Antibacterial p-Terphenyl with a Rare 2,2′-Bithiazole Substructure and Related Compounds Isolated from the Marine-Derived Actinomycete Nocardiopsis sp. HDN154086
Antibacterial p-Terphenyl with a Rare 2,2′-Bithiazole Substructure and Related Compounds Isolated from the Marine-Derived Actinomycete Nocardiopsis sp. HDN154086
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DOI：
10.1021/acs.jnatprod.0c01296
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发表时间：
2021-02-18
影响因子：
5.1
通讯作者：
Li, Dehai
中科院分区：
文献类型：
--
作者：
Chang, Yimin;Che, Qian;Li, Dehai
利用MS/MS分子网络和x射线衍射分析，从海洋沉积物来源的放线菌Nocardiopsis sp. HDN154086的培养物中获得了5个新的对terphenyl衍生物nocarterphenyls D-H(1-5)，并对其进行了表征。nocarterphenyl D(1)的骨架被定义为具有罕见的2,2'-双噻唑支架，首次自然存在，nocarterphenyl E-H（2-5）是具有罕见的硫醚连接脂肪酸甲酯取代的对terphenylquinones。化合物1对多种细菌具有良好的抑菌活性，MIC值在1.5 ~ 6.2 μ M之间；化合物2对MRSA的抑菌活性显著高于阳性对照环丙沙星。
Assisted by MS/MS-based molecular networking and X-ray diffraction analysis, five new p-terphenyl derivatives, namely, nocarterphenyls D-H (1-5), were obtained and characterized from the cultures of the marine sediment-derived actinomycete Nocardiopsis sp. HDN154086. The skeleton of nocarterphenyl D (1) was defined to possess a rare 2,2'-bithiazole scaffold, naturally occurring for the first time, and nocarterphenyls E-H (2-5) are p-terphenylquinones with unusual thioether linked fatty acid methyl ester substitutions. Compound 1 showed promising activity against multiple bacteria with MIC values ranging from 1.5 to 6.2 mu M, and 2 exhibited notable antibacterial activity against MRSA which surpassed the positive control ciprofloxacin.