Gestagens and endometrial carcinoma.
Gestagens and endometrial carcinoma.
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孕激素和子宫内膜癌。
DOI：
10.1016/0090-8258(76)90050-0
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发表时间：
1976
影响因子：
4.7
通讯作者：
E. Kohorn
中科院分区：
文献类型：
--
作者：
E. Kohorn
本文综述了促孕药物对子宫内膜癌的临床和细胞作用的研究现状。高剂量孕激素的总体反应率为32%，在分化良好的肿瘤中反应最大。然而，15%的低分化肿瘤确实有反应。肿瘤分化而不是患者年龄是反应的区分因素。激素的作用是直接作用于细胞，但在细胞水平上的确切作用机制尚待阐明。数据提出了一个更合理的方法来激素管理。
The current state of knowledge of the clinical and cellular effects of progestational agents in endometrial carcinoma is reviewed. High dose gestagens have an overall response rate of 32%, with most response in well-differentiated tumors. Nevertheless, 15% of poorly differentiated tumors do respond. Tumor differentiation rather than patient age is the discriminating factor in response. The effect of the hormone is a direct one on the cell but the precise mechanism of action at the cellular level awaits elucidation. Data are presented for a more rational approach to hormone administration.