Avian circovirus diseases: lessons for the study of PMWS
Avian circovirus diseases: lessons for the study of PMWS
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DOI：
10.1016/j.vetmic.2003.10.010
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发表时间：
2004-02-04
影响因子：
3.3
通讯作者：
Todd, D
中科院分区：
文献类型：
--
作者：
Todd, D
与鹦鹉喙羽病病毒（BFDV）、鸽子圆环病毒（PiCV）和鹅圆环病毒（GoCV）相关的疾病可与猪圆环病毒2型（PCV2）一起归类为圆环病毒科圆环病毒属成员，其临床病理特征与断奶后多系统消耗综合征（PMWS）相似，PCV2感染与PMWS有因果关系。巨噬细胞内的胞浆内botry样包涵体和T淋巴细胞和B淋巴细胞的耗竭是常见的组织病理学特征，在每种情况下，受影响的动物通常表现出不良的节俭和继发性感染的易感性，这表明潜在的免疫抑制。虽然对这些禽类疾病的研究相对较少，但对它们的研究可以为负责调查PMWS的人员在诊断、流行病学、发病机制和疾病控制等领域提供直接适用的经验教训。鸡贫血病毒（CAV）引起的疾病在组织病理学上不同于其他圆环病毒相关疾病，这与它作为旋转病毒属唯一成员的分类分离是一致的。最值得注意的是，CAV的靶细胞已被确定为造血细胞和前体T淋巴细胞，淋巴细胞耗损仅影响T细胞，发生在直接感染病毒的细胞中。尽管如此，CAV是研究得最好的环状病毒，并提供了病毒诱导的免疫抑制和病毒-病毒相互作用的极好例子。因此，对cav引起的疾病的研究可以提供有价值的、但不太直接适用的经验教训。(C) 2003 Elsevier B.V.版权所有
The diseases associated with psittacine beak and feather disease virus (BFDV), pigeon circovirus (PiCV) and goose circovirus (GoCV), which can be classified with porcine circovirus type 2 (PCV2) as members of the genus Circovirus of the family Circoviridae, have clinico-pathological features in common with post-weaning multisystemic wasting syndrome (PMWS), with which PCV2 infection is causally associated. Intracytoplasmic botryoid inclusions within macrophages and depletion of T and B lymphocytes are common histopathological features, and, in each case, affected animals usually exhibit ill-thrift and a predisposition to secondary infections, that is suggestive of an underlying immunosuppression. Although these avian diseases have been the subjects of relatively little research, their study can provide directly applicable lessons in the areas of diagnosis, epidemiology, pathogenesis and disease control for those charged with investigating PMWS. In keeping with its taxonomic separation as the only member of the genus Gyrovirus, the disease caused by chicken anaemia virus (CAV) differs histopathologically from the other circovirus-associated diseases. Most notably, the target cells of CAV have been identified as haemocytoblasts and precursor T lymphocytes, with lymphocyte depletion, which affects T cells only, occurring in cells directly infected with the virus. Nonetheless, CAV is the best-researched circovirus and provides excellent examples of both virus-induced immunosuppression and virus-virus interactions. The study of CAV-induced disease can therefore provide valuable, if less directly applicable lessons. (C) 2003 Elsevier B.V. All rights reserved.