Mesentery vascular metabolism of substance P.
Mesentery vascular metabolism of substance P.
复制标题
P物质的肠系膜血管代谢。
DOI：
10.1016/0304-4165(83)90259-3
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Ward,PE
中科院分区：
文献类型：
--
作者：
Palmieri,FE;Ward,PE
二肽基肽酶IV（EC 3.4.14.5）是一种代谢P物质的酶，存在于猪肠系膜动脉和主动脉的粗匀浆中。除了激肽和血管紧张素代谢酶血管紧张素I转化酶（EC 3.1.3.5）和氨肽酶M（EC 3.4.15.1）外3.4.11.2）密切相关。最高水平的二肽基肽酶IV被发现在表面膜富集的部分，是免疫学相同的肾刷缘结合酶。血管二肽基肽酶IV依次去除P物质的N-末端Arg 1-Pro2和Lys 3-Pro4二肽，并使具有生物活性的C-末端七肽产物暴露于血管氨肽酶的快速降解。
Dipeptidylpeptidase IV (EC 3.4.14.5), an enzyme which metabolizes substance P, is present in crude homogenates of hog mesenteric artery and aorta. Its subcellular localization is closely correlated with the plasma membrane marker enzyme 5′-nucleotidase (EC 3.1.3.5) in addition to the kinin and angiotensin metabolizing enzymes angiotensin I converting enzyme (EC 3.4.15.1) and aminopeptidase M (EC 3.4.11.2). The highest level of dipeptidylpeptidase IV is found on the surface membrane-enriched fraction and is immunologically identical to the kidney brush border-bound enzyme. Vascular dipeptidylpeptidase IV sequentially removes the N-terminal Arg1-Pro2and Lys3-Pro4dipeptides of substance P and exposes the biologically active C-terminal heptapeptide product to rapid degradation by vascular aminopeptidases.