Towards a recombinant antigen vaccine against Onchocerca volvulus.
Towards a recombinant antigen vaccine against Onchocerca volvulus.
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针对盘尾丝虫的重组抗原疫苗。
DOI：
10.1016/s1471-4922(01)02211-5
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
Abraham,David
中科院分区：
文献类型：
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作者：
Lustigman,Sara;James,EricR;Tawe,Wilson;Abraham,David
鉴定盘尾丝虫病潜在疫苗候选物的各种方法导致了重组蛋白的克隆，其在接种疫苗的小鼠中赋予保护作用。开发一种有效的盘尾丝虫病疫苗一直是埃德娜·麦康奈尔·克拉克基金会1985年至1999年支持的一项研究计划的重点。这里总结了用于克隆潜在的保护性抗原的方法和用一些抗原成功地接种动物的方法。
Various approaches to identify potential vaccine candidates against onchocerciasis resulted in the cloning of recombinant proteins, which confer protection in vaccinated mice. The development of an effective vaccine against onchocerciasis has been the focus of a research program supported by the Edna McConnell Clark Foundation from 1985 to 1999. The approaches used to clone potential protective antigens and the successful vaccination of animals with some of the antigens are summarized here.