Distinctive FDG and FES accumulation pattern of two tamoxifen-treated patients with endometrial hyperplasia
Distinctive FDG and FES accumulation pattern of two tamoxifen-treated patients with endometrial hyperplasia
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DOI：
10.1007/s12149-007-0075-2
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发表时间：
2008
影响因子：
2.6
通讯作者：
T. Tsujikawa;H. Okazawa;Y. Yoshida;T. Mori;Masato Kobayashi;T. Tsuchida;Y. Fujibayashi
中科院分区：
文献类型：
--
作者：
T. Tsujikawa;H. Okazawa;Y. Yoshida;T. Mori;Masato Kobayashi;T. Tsuchida;Y. Fujibayashi
16α-[18F]Fluoro-17β-estradiol （FES）是一种雌激素受体（ER）配体，用于检测ER阳性的恶性肿瘤，如乳腺癌。我们最近报道了fes和2-[18F]氟-2-脱氧-d -葡萄糖(FDG)-正电子发射断层扫描（PET）联合扫描用于子宫内膜肿瘤鉴别诊断的可行性。fgs - pet检测的ER表达在子宫内膜增生中保持不变，而FDG-PET检测的葡萄糖代谢加速的子宫内膜癌则认为ER减少。我们报告了两名绝经后的患者，在细胞学和/或磁共振成像（MRI）的基础上怀疑子宫内膜癌，他们在接受乳腺癌手术后接受了他莫昔芬治疗。盆腔MRI提示子宫内膜癌，fdg和FES-PET未见异常示踪剂积累。术后组织病理学检查显示病变为子宫内膜增生，无恶性发现。FES- pet使我们能够无创地评估子宫内膜的ERα表达，而使用FES- pet评估ER表达需要仔细注意激素治疗的影响，因为他莫昔芬极大地影响了子宫内膜增生的FES积累，而子宫内膜增生应该是一个FES强烈的病变。
16α-[18F]Fluoro-17β-estradiol (FES) is an estrogen receptor (ER) ligand used for the detection of ER-positive malignant tumors such as breast cancer. We recently reported the feasibility of combined FES-and 2-[18F]fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) scans for the differential diagnosis of endometrial tumors. ER expression measured by FES-PET was preserved in endometrial hyperplasia, whereas ERs were assumed to be reduced in endometrial carcinoma with accelerated glucose metabolism measured by FDG-PET. We report two postmenopausal patients under suspicion of endometrial carcinoma on the basis of cytology and/or magnetic resonance imaging (MRI), who were on tamoxifen treatment since undergoing surgery for breast cancer. Pelvic MRI suggested endometrial carcinomas, whereas FDG-and FES-PET showed no abnormal tracer accumulation. A postoperative histopathologic examination revealed that the lesions were endometrial hyperplasias with no malignant findings. FES-PET enables us to evaluate the ERα expression of endometrium noninvasively, whereas the evaluation of ER expression using FES-PET requires careful attention regarding the influence of hormonal therapy because tamoxifen greatly affects FES accumulation of even endometrial hyperplasia, which should be an FES-avid lesion.