CELL-KINETICS IN THE MOUSE SMALL-INTESTINE DURING IMMEDIATE POSTNATAL LIFE
CELL-KINETICS IN THE MOUSE SMALL-INTESTINE DURING IMMEDIATE POSTNATAL LIFE
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DOI：
10.1007/bf02932850
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发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
WRIGHT, NA
中科院分区：
文献类型：
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作者：
ALNAFUSSI, AI;WRIGHT, NA
研究了新生Balb/c小鼠从出生后第1天到第21天的小肠细胞增殖动力学。采用显微切割技术结合中期阻滞法，测定腺窝中功能区室和增殖区室的大小以及细胞产生率。研究断乳对细胞增殖的影响。在21天内，细胞增殖以及功能和增殖区室的大小持续增加。细胞增殖的速度比成年动物慢。在出生后的第3周，细胞产生率急剧增加。细胞增殖速度更快，在常规断奶窝比非断奶组。新生小鼠的肠粘膜不像成年小鼠那样处于稳态状态;细胞产生率超过细胞损失率。
The cell proliferation kinetics in the small intestine of newborn Balb/c mice were studied, from day 1 through to day 21 after birth. The size of the functional compartment and the proliferation compartment was determined as well as the cell production rate in the crypt using the microdissection technique combined with metaphase arrest method. The effect of weaning on cell proliferation was studied. There is a continuous increase in cell proliferation and in the size of the functional and proliferative compartment over the 21 days. Cell proliferation proceeds at a slower rate than in adult animals. There is a sharp increase in cell production rate during the 3rd wk of postnatal life. Cell proliferation was faster in conventionally weaned litters than the nonweaned group. The intestinal mucosa in newborn mice is not in a steady-state condition as in adults; cell production rate exceeds cell loss.