Apomorphine: A potential modifier of amyloid deposition in Parkinson's disease?
Apomorphine: A potential modifier of amyloid deposition in Parkinson's disease?
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阿朴吗啡：帕金森病淀粉样蛋白沉积的潜在调节剂？
DOI：
10.1002/mds.26422
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发表时间：
2016
影响因子：
8.6
通讯作者：
D. Burn
中科院分区：
文献类型：
--
作者：
A. Yarnall;T. Lashley;H. Ling;A. J. Lees;Shirley Coleman;S. O'sullivan;Y. Compta;T. Révész;D. Burn
来自临床和病理学研究的证据表明，α-突触核蛋白和β-淀粉样蛋白在PD相关痴呆的病理生理学中发挥作用。最近的研究表明，在皮下注射阿扑吗啡的转基因小鼠阿尔茨海默病模型中，记忆力得到改善，淀粉样β蛋白负荷减少。这项工作的目的是确定在PD的临床病理学研究中，死前暴露于阿扑吗啡是否与脑组织中淀粉样蛋白β水平降低相关。
Evidence from clinical and pathological studies suggests a role for both alpha‐synuclein and amyloid‐beta in the pathophysiology of dementia associated with PD. Recent work demonstrated improvement in memory and reduced amyloid‐beta burden in transgenic murine Alzheimer's models given subcutaneous apomorphine. The aim of this work was to determine whether antemortem exposure to apomorphine was associated with lower levels of amyloid‐beta in brain tissue in a clinicopathological study of PD.
影响因子：
--
作者：
Kotzbauer, Paul T.;Cairns, Nigel J.;Campbell, Meghan C.;Willis, Allison W.;Racette, Brad A.;Tabbal, Samer D.;Perlmutter, Joel S.
通讯作者：
Perlmutter, Joel S.
影响因子：
29
作者：
Tsuang, Debby;Leverenz, James B.;Lopez, Oscar L.;Hamilton, Ronald L.;Bennett, David A.;Schneider, Julie A.;Buchman, Aron S.;Larson, Eric B.;Crane, Paul K.;Kaye, Jeffrey A.;Kramer, Patricia;Woltjer, Randy;Trojanowski, John Q.;Weintraub, Daniel;Chen-Plotkin, Alice S.;Irwin, David J.;Rick, Jacqueline;Schellenberg, Gerard D.;Watson, G. Stennis;Kukull, Walter;Nelson, Peter T.;Jicha, Gregory A.;Neltner, Janna H.;Galasko, Doug;Masliah, Eliezer;Quinn, Joseph F.;Chung, Kathryn A.;Yearout, Dora;Mata, Ignacio F.;Wan, Jia Y.;Edwards, Karen L.;Montine, Thomas J.;Zabetian, Cyrus P.
通讯作者：
Zabetian, Cyrus P.