Effects of atorvastatin and pravastatin on glucose tolerance in diabetic rats mildly induced by streptozotocin
Effects of atorvastatin and pravastatin on glucose tolerance in diabetic rats mildly induced by streptozotocin
复制标题
DOI：
10.1248/bpb.26.1681
复制
发表时间：
2003-12-01
影响因子：
2
通讯作者：
Ichihara, K
中科院分区：
文献类型：
--
作者：
Kanda, M;Satoh, K;Ichihara, K
阿托伐他汀和普伐他汀对链脲佐菌素 24 mg/kg 静脉注射引起的轻度糖尿病大鼠葡萄糖耐量的影响被研究了。非糖尿病和糖尿病大鼠每天口服 0.5% 羧甲基纤维素（对照）、8 mg/kg 阿托伐他汀或 8 mg/kg 普伐他汀，持续 6 周。给药后1、2、3和6周进行口服葡萄糖耐量试验(OGTT)。糖尿病大鼠在OGTT前测量的血糖和血浆胰岛素水平与非糖尿病大鼠没有差异。然而，糖尿病大鼠对 OGTT 的高血糖反应明显超过非糖尿病大鼠。糖尿病大鼠因OGTT增加的血浆胰岛素似乎低于非糖尿病大鼠。他汀类药物治疗 1 周并没有明显改变 OGTT 引起的高血糖，尽管存在一些显着差异。给药后2周以上，阿托伐他汀治疗的糖尿病大鼠在摄入葡萄糖后的几个时间点的血糖水平显着高于对照糖尿病大鼠的相应水平。阿托伐他汀和普伐他汀均不会改变 OGTT 诱导的胰岛素分泌。他汀类药物，尤其是阿托伐他汀，可能会影响轻度糖尿病大鼠的糖耐量，而不改变胰岛素分泌。
Effects of atorvastatin and pravastatin on glucose tolerance in mildly induced diabetic rats by streptozotocin at 24 mg/kg, i.v. were studied. Non-diabetic and diabetic rats were given orally 0.5% carboxymethylcellulose (control), 8 mg/kg atorvastatin or 8 mg/kg pravastatin once a day for 6 weeks. An oral glucose tolerance test (OGTT) was carried out 1, 2, 3, and 6 weeks after the administration. The blood glucose and plasma insulin levels measured before OGTT in the diabetic rats were not different from those in the non-diabetic rats. However, the hyperglycemic response to OGTT in the diabetic rats significantly exceeded that in the non-diabetic rats. The plasma insulin increased by OGTT in the diabetic rats appeared to be lower than that in the non-diabetic rats. Statin treatments for 1 week did not modify the OGTT-induced hyperglycemia appreciably, although there were some significant differences. More than 2 weeks after administration, the blood glucose levels at several time points after a glucose intake in the atorvastatin-treated diabetic rats were significantly higher than the respective levels in the control diabetic rats. Neither atorvastatin nor pravastatin modified the OGTT-induced insulin secretion. Statins, especially atorvastatin, may influence the glucose tolerance in mildly induced diabetic rats without alterations of insulin secretion.