Brief Report: Effectiveness of Combination Antiretroviral Therapy on Survival and Opportunistic Infections in a Developing World Setting: An Observational Cohort Study
Brief Report: Effectiveness of Combination Antiretroviral Therapy on Survival and Opportunistic Infections in a Developing World Setting: An Observational Cohort Study
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简要报告：抗逆转录病毒联合疗法对发展中国家生存和机会性感染的有效性：一项观察性队列研究
DOI：
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
S. Tabet
中科院分区：
文献类型：
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作者：
Daniel M. Corey;H. Kim;R. Salazar;Ricardo Illescas;J. Villena;Luis Gutierrez;Jorge Sanchez;S. Tabet
背景：抗逆转录病毒治疗（ART）在发展中国家的长期有效性尚未得到很好的证实。方法：1996年在秘鲁利马Almenara医院HIV门诊建立观察性数据库。所有564名最初接受抗逆转录病毒治疗的hiv感染者（平均CD4细胞计数为91个/mm3）接受联合抗逆转录病毒治疗。结果：第2年总生存率为96%，第4年为94%，第5年为91%。在CD4计数<100细胞/mm3的患者中，3年的总生存率为95%。20%的人在接受抗逆转录病毒治疗时发生机会性感染。与接受2种逆转录酶抑制剂和1种非核苷类逆转录酶抑制剂或3种逆转录酶抑制剂的患者相比，接受2种逆转录酶抑制剂加1种蛋白酶抑制剂的患者在治疗的第一年生存率略高，机会性疾病较少。结论：本研究证明了抗逆转录病毒治疗在发展中国家城市环境中的长期有效性。它提供了证据，证明了继续开展全球筹资行动，为发展中国家提供广泛的艾滋病毒治疗的重要性。
Background:The prolonged effectiveness of antiretroviral therapy (ART) in a developing country is not well established. Methods:An observational database was established at the HIV clinic of the Almenara Hospital in Lima, Peru in 1996. All 564 initially antiretroviral-naive HIV-infected persons (mean CD4 count of 91 cells/mm3) who received combination ART were followed over time. Results:The overall survival rate was 96% at year 2, 94% at year 4, and 91% at year 5. Among persons who initiated therapy with CD4 counts <100 cells/mm3, the overall survival rate at 3 years was 95%. Opportunistic infections while on ART occurred in 20% of persons. Patients who received 2 reverse transcriptase (RT) inhibitors plus a protease inhibitor had slightly better survival rates and less opportunistic disease in the first year of therapy as compared with those receiving 2 RT inhibitors and a nonnucleoside reverse transcriptase inhibitor or 3 RT inhibitors. Conclusions:This study demonstrates the long-term effectiveness of ART in a developing country urban setting. It provides evidence of the importance of continuing global financing initiatives to provide widespread HIV therapy for countries in the developing world.
在资源有限的环境中预防和治疗人类免疫缺陷病毒/获得性免疫缺陷综合症。
影响因子：
11.1
作者：
Hogan,DanielR;Salomon,JoshuaA
通讯作者：
Salomon,JoshuaA