Laser-assisted cerebrospinal fluid leak repair: An animal model to test feasibility
Laser-assisted cerebrospinal fluid leak repair: An animal model to test feasibility
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DOI：
10.1016/j.otohns.2007.05.060
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发表时间：
2007-11-01
影响因子：
3.4
通讯作者：
Cohen, Noam A.
中科院分区：
文献类型：
--
作者：
Bleier, Benjamin S.;Palmer, James N.;Cohen, Noam A.
目的：为了测试的可行性，激光组织焊接作为一种方法，创造一个鼻内组织债券的目的，脑脊液漏repair.Study设计和设置：一个808 nm的二极管激光器使用了42%的白蛋白焊料，以创建激光焊接在羊鼻中隔粘膜，骨膜，和原位兔上颌窦粘膜。每种条件测试五次。组进行了比较Kruskal-Wallis非参数方差分析（ANOVA）和事后多重比较检验与Bonferroni test.Results：羊中隔粘膜（34.88 +/- 3.49 mmHg）和骨膜（30.02 +/- 2.23 mmHg）的爆破压力显着高于缝合修复。在兔原位上颌窦粘膜中达到69.58 ± 2.85 mmHg的爆破压力。结论：激光焊接能够产生爆破强度超过人类颅内压的组织债券。该技术能够产生瞬间经鼻组织粘合，爆破压力超过人类颅内压，这使得该技术成为脑脊液漏修复的理想选择。(C)2007年美国耳鼻咽喉头颈外科学会基金会。All rights reserved.
OBJECTIVES: To test the feasibility of laser tissue welding as a method of creating an endonasal tissue bond for the purpose of cerebrospinal fluid leak repair.STUDY DESIGN AND SETTING: An 808 nm diode laser was used with a 42% albumin solder to create laser welds in sheep nasal septal mucosa, periosteum, and in situ rabbit maxillary sinus mucosa. Each condition was tested five times. Groups were compared with Kruskal-Wallis nonparametric analysis of variance (ANOVA) and post-hoc multiple-comparisons testing with the Bonferroni test.RESULTS: The burst pressures of sheep septal mucosa (34.88 +/- 3.49 mmHg) and periosteum (30.02 +/- 2.23 mmHg) were significantly higher than suture repair. A burst pressure of 69.58 +/- 2.85 mmHg was achieved in rabbit in situ maxillary sinus mucosa.CONCLUSION: Laser welding is capable of producing tissue bonds whose burst strength exceeds that of human intracranial pressure.SIGNIFICANCE: This is the first study to examine the feasibility of laser tissue welding in endonasal tissues. The ability to produce instant transnasal tissue bonds with burst pressures that exceed human intracranial pressure make this technology ideal for cerebrospinal fluid leak repair.(C) 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.