Attentional Load Effects on Beta Oscillations in Healthy and Schizophrenic Individuals.
Attentional Load Effects on Beta Oscillations in Healthy and Schizophrenic Individuals.
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DOI：
10.3389/fpsyt.2015.00149
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发表时间：
2015
影响因子：
4.7
通讯作者：
Spencer KM
中科院分区：
文献类型：
--
作者：
Ghorashi S;Spencer KM
注意力缺陷在精神分裂症的认知障碍中最为突出。鉴于精神分裂症也以高频振荡异常为特征，我们研究了精神分裂症的注意力功能是否与操纵注意力负荷的视觉辨别任务中的高频振荡异常有关。 16 名健康对照受试者 (HC) 和 23 名慢性精神分裂症患者 (SZ) 区分了目标椎间盘 (p = 0.2) 和标准椎间盘 (p = 0.8)。通过改变目标盘和标准盘之间跨块的大小差异来控制注意力负荷：大（简单条件）、中（中等）和小（困难）。记录脑电图并使用 Morlet 小波变换分析标准刺激引起的振荡。受试者的表现随着注意力负荷的增加而下降，但 HC 和 SZ 没有差异。注意负荷增加了 HC 中额叶、顶叶和枕叶电极部位的 β 锁相因子，但不增加 SZ 中的β相锁定因子。然而，在 SZ 中，β 注意力负荷效应与整体 d' 之间存在相关性，这表明高绩效的 SZ 具有相对正常的 β 注意力负荷效应。这些结果表明，注意力负荷的变化与β振荡有关，并提供了精神分裂症中注意力功能障碍和β生成神经回路之间的联系。
Attentional deficits are prominent among the cognitive disturbances found in schizophrenia. Given that schizophrenia is also characterized by abnormalities in high-frequency oscillations, we investigated whether attentional function in schizophrenia is related to abnormalities in high-frequency oscillations in a visual discrimination task in which attentional load was manipulated. Sixteen healthy control subjects (HC) and 23 chronic schizophrenia patients (SZ) discriminated between target discs (p = 0.2) and standard discs (p = 0.8). Attentional load was manipulated by varying the size difference between the target and standard discs across blocks: large (Easy condition), medium (Medium), and small (Difficult). The electroencephalogram was recorded and the oscillations evoked by the standard stimuli were analyzed using the Morlet wavelet transform. Subjects’ performance decreased as attentional load increased, but HC and SZ did not differ. Attentional load increased β phase-locking factor at frontal, parietal, and occipital electrode sites in HC but not SZ. In SZ, however, there was a correlation between the β attentional load effect and overall d′, indicating that high-performing SZ had relatively normal β attentional load effects. These results show that variations in attentional load are associated with β oscillations and provide a link between attentional dysfunction and β-generating neural circuitry in schizophrenia.