Cigarette smoke and inflammation: role in cerebral aneurysm formation and rupture.
Cigarette smoke and inflammation: role in cerebral aneurysm formation and rupture.
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DOI：
10.1155/2012/271582
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发表时间：
2012
影响因子：
4.6
通讯作者：
Dumont AS
中科院分区：
文献类型：
--
作者：
Chalouhi N;Ali MS;Starke RM;Jabbour PM;Tjoumakaris SI;Gonzalez LF;Rosenwasser RH;Koch WJ;Dumont AS
吸烟是蛛网膜下腔出血的一个确定的危险因素，但其潜在的机制在很大程度上是未知的。最近的数据表明炎症在脑动脉瘤的发展中起作用。因此，伴随香烟烟雾暴露的炎症可能是脑动脉瘤发生、发展和破裂的关键途径。炎症反应的各种成分似乎都参与其中，包括粘附分子、细胞因子、活性氧、白细胞、基质金属蛋白酶和血管平滑肌细胞。表征伴随香烟烟雾暴露的炎症反应的分子基础将为未来的靶向治疗提供合理的方法。在本文中，我们回顾了目前的知识体系涉及香烟烟雾引起的炎症在脑动脉瘤形成/破裂，并试图强调未来的调查的重要途径。
Smoking is an established risk factor for subarachnoid hemorrhage yet the underlying mechanisms are largely unknown. Recent data has implicated a role of inflammation in the development of cerebral aneurysms. Inflammation accompanying cigarette smoke exposure may thus be a critical pathway underlying the development, progression, and rupture of cerebral aneurysms. Various constituents of the inflammatory response appear to be involved including adhesion molecules, cytokines, reactive oxygen species, leukocytes, matrix metalloproteinases, and vascular smooth muscle cells. Characterization of the molecular basis of the inflammatory response accompanying cigarette smoke exposure will provide a rational approach for future targeted therapy. In this paper, we review the current body of knowledge implicating cigarette smoke-induced inflammation in cerebral aneurysm formation/rupture and attempt to highlight important avenues for future investigation.