Hyalinizing clear cell carcinoma of the hard palate
Hyalinizing clear cell carcinoma of the hard palate
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DOI：
10.1258/002221504323086624
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发表时间：
2004-05-01
影响因子：
1.7
通讯作者：
Teh, JEK
中科院分区：
文献类型：
--
作者：
Chao, TK;Tsai, CC;Teh, JEK
涎腺透明细胞癌（HCCC）是近年来才发现的一种新疾病。它很罕见，标准治疗方法仍在研究中。这是一个42岁女性HCCC的报告，她表现为无痛的粘膜下硬腭肿块，持续三年。广泛切除肿瘤及下腭和上颌骨。病理检查显示典型的透明细胞排列于吻合的小梁、索、巢或实片状，间质透明。这些透明细胞在周期性酸-希夫反应（PAS）中呈阳性，但在粘蛋白染色中呈阴性。免疫组化结果显示，肿瘤细胞角蛋白阳性，肌动蛋白阴性。随访8个月无复发及远处转移。
Hyalinizing clear cell carcinoma (HCCC) of the salivary gland is new disease only recognized in recent years. It is rare and the standard treatment is still under investigation. This is a report of a 42-year-old female with HCCC who presented with a painless submucosal hard palatal mass of three years duration. Wide excision of the tumour and the underlying palatal and maxillary bones was performed. Pathological examination revealed typical clear cells arranged in anastomosing trabeculae, cords, nests, or solid sheets with a hyalinizing stroma. These clear cells were positive for the periodic acid-Schiff (PAS) reaction but were negative for the mucin stain. Immunohistochemically, these neoplastic cells were positive for cytokeratin, but negative for actin. No recurrence nor distant metastasis was found during the eight-month follow-up period.