Macrophage turnover, division and activation within developing, peak and "heated" tuberculous lesions produced in rabbits by BCG
Macrophage turnover, division and activation within developing, peak and "heated" tuberculous lesions produced in rabbits by BCG
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DOI：
10.1016/s1472-9792(03)00048-9
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发表时间：
2003-01-01
期刊：
影响因子：
3.2
通讯作者：
Dannenberg, AM
中科院分区：
文献类型：
--
作者：
Dannenberg, AM
这篇综述是对我们九篇关于卡介苗在兔子体内产生的真皮结核病灶中巨噬细胞动力学的实验病理学论文的综合和分析。此次提出的目的是总结活动性和实质上加热的结核性病变中的巨噬细胞动力学，并表明杆菌在许多小的停滞性结核性病变的活肉芽组织中频繁繁殖和被破坏。单核细胞（MN）（主要是巨噬细胞和一些中型和大型淋巴细胞）的更新在BCG病变中最快 2-3周（结核菌素敏感性和获得性细胞耐药性达到峰值时）。此时，与之前或之后相比，更多的巨噬细胞进入，更多的死亡或留下，更多的留在现场，更多的巨噬细胞被激活。在此之前，宿主没有迟发型超敏反应（DTH）和细胞介导的免疫（CMI），因此没有发生抗原特异性的炎症反应增强。此后，杆菌及其抗原产物减少，细胞浸润和活化的刺激减少。在“加热”的病变中，MN更新仍然发生，但有所减少。活的非活化巨噬细胞持续进入结核性病变的活部分，为结核杆菌在再次被宿主的DTH和CMI抑制之前可以繁殖提供了新鲜的细胞内位点。在结核病中，长期的细菌休眠可能仅存在于不存在活宿主细胞的干酪样坏死组织中。 (C) 2003 Elsevier Ltd. 保留所有权利。
This review is a synthesis and analysis of our nine experimental pathology papers on macrophage kinetics in dermal tuberculous lesions produced in rabbits by BCG. It is presented at this time to summarize the macrophage kinetics in both active and essentially heated tuberculous lesions and to suggest that the bacilli frequently multiply and are destroyed in the viable granulation tissue of many small arrested tuberculous lesions.The turnover of mononuclear cells (MN)-which were mostly macrophages with some medium and large lymphocytes-was most rapid in BCG lesions at 2-3 weeks (when tuberculin sensitivity and acquired cellular resistance were at their peaks). At this time, more macrophages entered, more died or left, more remained at the site, and more became activated than before or afterwards. Before this time, the host had no delayed-type hypersensitivity (DTH) and cell-mediated immunity (CMI), so that no antigen-specific enhancement of the inflammatory response occurred. After this time, the bacilli and their antigenic products had decreased, so that the stimuli for cell infiltration and activation were reduced. In "heated" lesions, the MN turnover still occurred, but was decreased.The continuous entry of live non-activated macrophages into the viable parts of tuberculous lesions provides fresh intracellular sites where tubercle bacilli may multiply before they are again inhibited by the DTH and CMI of the host. In tuberculosis, bacillary dormancy of Long duration may only be present in caseous necrotic tissue where no Live host cells exist. (C) 2003 Elsevier Ltd. All rights reserved.