Nitric oxide in the ventrolateral medulla regulates sympathetic responses to systemic hypoxia in pigs.
Nitric oxide in the ventrolateral medulla regulates sympathetic responses to systemic hypoxia in pigs.
复制标题
腹外侧髓质中的一氧化氮调节猪对全身缺氧的交感神经反应。
DOI：
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
H. Seller
中科院分区：
文献类型：
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作者：
J. Zanzinger;J. Czachurski;H. Seller
在麻醉猪（n = 21）上研究了一氧化氮（NO）在缺氧时交感神经活动调节中的作用。缺氧（吸入空气中O2浓度分数= 0.1）增加肺动脉压，降低动脉血压和外周血管阻力。肾交感神经活动（RSNA）在缺氧过程中适度增加，但在复氧瞬间下降。在延髓腹侧表面注射N-硝基-L-精氨酸（0.3mmol/l）阻断NO合成，可显著增强缺氧引起的RSNA增加，并消除复氧引起的RSNA反应。此外，L-NNA显着降低外周缺氧血管舒张，但不影响肺血管收缩。无活性的对映体-NNA在相同浓度下没有可测量的影响。NO供体S-亚硝基-N-乙酰青霉胺（0.1mmol/l）能有效地抑制n-NNA的作用。去传入（颈动脉窦和迷走神经切断）取消交感神经对缺氧的反应和NO的调制。结果表明，外周化学感受器的激活诱导NO的释放在VLM缓冲缺氧期间的交感兴奋，并有助于在复氧期间的交感抑制。
The role of nitric oxide (NO) in the regulation of sympathetic activity during hypoxia was studied in anesthetized pigs ( n = 21). Hypoxia (fractional concentration of O2 in inspired air = 0.1) increased pulmonary arterial pressure and decreased arterial blood pressure and peripheral vascular resistance. Renal sympathetic nerve activity (RSNA) was moderately increased during hypoxia but decreased instantaneously on reoxygenation. Blockade of NO synthesis by N G-nitro-l-arginine (l-NNA, 0.3 mmol/l) administered to the ventral surface of the medulla oblongata (VLM) significantly enhanced RSNA increases induced by hypoxia and abolished the RSNA response to reoxygenation. Furthermore,l-NNA significantly reduced peripheral hypoxic vasodilation but did not affect pulmonary vasoconstriction. The inactive enantiomerd-NNA had no measurable effects at the same concentration. Actions ofl-NNA were effectively counteracted by the NO donor S-nitroso- N-acetyl-penicillamine (0.1 mmol/l). Deafferentiation (carotid sinus and vagal nerves cut) abolished sympathetic responses to hypoxia and their modulation by NO. The results suggest that activation of peripheral chemoreceptors induces NO release in the VLM that buffers sympathoexcitation during hypoxia and contributes to sympathoinhibition during reoxygenation.
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影响因子：
20.1
作者：
I. Sakuma;H. Togashi;M. Yoshioka;Hideya Saito-;M. Yanagida;M. Tamura;Takeshi Kobayashi;H. Yasuda
通讯作者：
I. Sakuma;H. Togashi;M. Yoshioka;Hideya Saito-;M. Yanagida;M. Tamura;Takeshi Kobayashi;H. Yasuda
中枢心血管调节中的兴奋性氨基酸受体。
DOI：
10.3109/10641969509087056
发表时间：
1995
期刊：
Clinical and experimental hypertension (New York, N.Y. : 1993)
影响因子：
--
作者：
Gordon,FJ
通讯作者：
Gordon,FJ
一氧化氮是否参与人类中枢交感神经流出的强直性抑制？
DOI：
10.1161/01.hyp.24.4.439
发表时间：
1994
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
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作者：
Hansen,J;Jacobsen,TN;Victor,RG
通讯作者：
Victor,RG
麻醉大鼠对一氧化氮合酶抑制的不同交感神经反应。
DOI：
10.1152/ajpregu.1995.269.4.r807
发表时间：
1995
期刊：
The American journal of physiology
影响因子：
--
作者：
Hirai,T;Musch,TI;Morgan,DA;Kregel,KC;Claassen,DE;Pickar,JG;Lewis,SJ;Kenney,MJ
通讯作者：
Kenney,MJ