Chromatin modification and remodeling during early seed development
Chromatin modification and remodeling during early seed development
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DOI：
10.1016/j.gde.2007.09.004
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发表时间：
2007-12-01
影响因子：
4
通讯作者：
Grossniklaus, Ueli
中科院分区：
文献类型：
--
作者：
Baroux, Celia;Pien, Stephane;Grossniklaus, Ueli
种子发育始于双受精，两个精子与一个雌配子、卵和中央细胞融合，分别产生胚和胚乳。将两个亲本基因组结合成一个独特的合子基因组肯定是第一个需要大规模染色质修饰和重塑的事件。虽然对分子机制知之甚少，但最近取得的进展允许在受精时实时成像亲本染色质动态。进一步的生长和图案化过程将塑造未来的植物幼苗及其周围的营养组织。过去十年的研究确定了参与这些过程的关键染色质修饰剂。然而，这些修改介导的动力学，特别是由Polycomb组复合物才开始被理解。由于受精产物的相对不可及性，改变与早期种子发育相关的染色质状态的精确分子机制仍然难以解决。尽管如此，随着体内成像技术、激光捕获解剖和全基因组染色质修饰分析的出现，未来有望有新的令人兴奋的发现。
Seed development starts at double fertilization when two sperms fuse with a female gamete, the egg and central cell, giving rise to the embryo and endosperm, respectively. Uniting two parental genomes into one, unique, zygotic genome is certainly the first event requiring large-scale chromatin modifications and remodeling. Although little is known about the molecular mechanisms, recent progress was made allowing live imaging of parental chromatin dynamics at fertilization. Further growth and patterning processes will shape the future plant seedling and its surrounding nurse tissue. Studies over the last decade identified key chromatin modifiers involved in these processes. However, the dynamics of these modifications mediated, in particular, by the Polycomb group complexes only start to be understood. The precise molecular mechanisms altering chromatin state in relation to early seed development remains difficult to address because of the relative inaccessibility of the fertilization products. Nonetheless, with the emergence of in vivo imaging techniques, laser-capture dissection, and genome-wide chromatin modification profiling, the future promises new, exciting discoveries.