Evaluating cluster alarms: A space-time scan statistic and brain cancer in Los Alamos, New Mexico
Evaluating cluster alarms: A space-time scan statistic and brain cancer in Los Alamos, New Mexico
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DOI：
10.2105/ajph.88.9.1377
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发表时间：
1998-09-01
影响因子：
12.7
通讯作者：
Key, CR
中科院分区：
文献类型：
--
作者：
Kulldorff, M;Athas, WF;Key, CR
目标。本文提出了一种用于评估时空集群警报的时空扫描统计量，并以新墨西哥州洛斯阿拉莫斯最近的一个脑癌集群警报为例说明了该方法。时空扫描统计数据考虑了集群警报中固有的预选偏差和多次测试。混杂因素和时间趋势可以根据结果进行调整。在洛斯阿拉莫斯观察到的脑癌过多在统计学上并不显著。时空扫描统计作为一种筛选工具很有用，用于评估哪些集群警报值得进一步调查，哪些集群可能是偶然发生的。
Objectives. This article presents a space-time scan statistic, useful for evaluating space-time cluster alarms, and illustrates the method on a recent brain cancer cluster alarm in Los Alamos, NM.Methods. The space-time scan statistic accounts for the preselection bias and multiple testing inherent in a cluster alarm. Confounders and time trends can be adjusted forResults. The observed excess of brain cancer in Los Alamos was not statistically significant.Conclusions. The space-time scan statistic is useful as a screening tool for evaluating which cluster alarms merit further investigation and which clusters are probably chance occurrences.