Effects of licence change on prescribing and poisons enquiries for antipsychotic agents in England and Scotland
Effects of licence change on prescribing and poisons enquiries for antipsychotic agents in England and Scotland
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DOI：
10.1046/j.1365-2125.2003.01792.x
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发表时间：
2003-06-01
影响因子：
3.4
通讯作者：
Kelly, CA
中科院分区：
文献类型：
--
作者：
Bateman, DN;Good, AM;Kelly, CA
目的是研究硫利达嗪在2000年底的抗精神病药物的处方，在英格兰和苏格兰的许可证变化的影响，并调查毒物信息查询的变化，爱丁堡，poisonadmissions.Methods抗精神病药物的处方数据，获得英格兰和苏格兰和季度趋势检查2000年和2001年。访问英国国家毒物信息服务网站TOXBASE的抗精神病药物的产品进行了检查，在同一时期。对于苏格兰的电话查询数据，并录取数据的爱丁堡毒药单位进行了评估。中毒的趋势进行了比较处方changes.Results在英格兰处方硫利达嗪迅速下降，在2001年从约35%的市场份额不到5%，并取代利培酮，氯丙嗪和奥氮平。TOXBASE访问从39.3%的抗精神病药物下降到4.4%。氯丙嗪、奥氮平和利培酮的使用增加。在苏格兰，硫利达嗪的处方与英格兰的变化相似，但主要被氯丙嗪取代。这些变化反映在TOXBASE检索、电话询问和住院病人的入院情况中。硫利达嗪处方号码的TOXBASE访问的比例增加后，许可证的变化。结论许可证的变化产生了快速变化的处方行为在3个月内。英格兰和苏格兰的处方行为是不同的。处方的变化反映在英格兰和苏格兰的毒药信息访问的变化，以及爱丁堡的入院情况。TOXBASE访问硫利达嗪处方的比例增加表明医生可能已经更加意识到其潜在的毒性。
Aims To examine the effect of licence change for thioridazine at the end of 2000 on the prescription of antipsychotic drugs in England and Scotland, and investigate changes in poisons information inquiries and, for Edinburgh, poisons admissions.Methods Prescription data for antipsychotic drugs were obtained for England and Scotland and quarterly trends examined for 2000 and 2001. Accesses to the UK National Poisons Information Service website TOXBASE for antipsychotic products were examined for the same period. For Scotland telephone enquiry data, and admission data to the Edinburgh Poisons Unit were also evaluated. Trends in poisonings were compared with prescribing change.Results In England prescriptions for thioridazine fell rapidly in 2001 from approximately 35% of market share to less than 5%, and were replaced by risperidone, chlorpromazine and olanzapine. TOXBASE accesses fell from 39.3% of antipsychotics to 4.4%. Accesses for chlorpromazine, olanzapine and risperidone increased. In Scotland prescribing of thioridazine was similar to changes in England, but it was principally replaced by chlorpromazine. These changes were mirrored by TOXBASE accesses, telephone enquiries and in-patient admissions. The ratio of TOXBASE accesses for thioridazine to prescription numbers for the drug increased after the licence change.Conclusions Licence change produced rapid change in prescribing behaviour within 3 months. Prescribing behaviour in England and Scotland was different. Changes in prescribing were mirrored by changes in accesses for poisons information in both England and Scotland, and in Edinburgh by hospital admissions. The increase in the ratio of TOXBASE accesses to prescriptions for thioridazine suggests doctors may have become more aware of its potential toxicity.