Frequency-specific adaptation in human auditory cortex depends on the spectral variance in the acoustic stimulation
Frequency-specific adaptation in human auditory cortex depends on the spectral variance in the acoustic stimulation
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DOI：
10.1152/jn.00907.2012
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发表时间：
2013-04-01
影响因子：
2.5
通讯作者：
Obleser, Jonas
中科院分区：
文献类型：
--
作者：
Herrmann, Bjoern;Henry, Molly J.;Obleser, Jonas
Herrmann B，Henry MJ，Obleser J.人类听觉皮质的特定频率适应依赖于声刺激中的频谱变化。神经生理学杂志109：2086-2096,2013。2013年1月23日首次出版；doi：10.1152/jn.00907.2012。-在听觉皮质，对刺激音频反应最好的区域激活和随后的适应最强，对其他频率反应最好的区域较小。先前研究人类神经适应传播的尝试研究了事件相关电位的听觉皮层N1成分。然而，重要的是，最近在动物身上的研究表明，神经反应特性并不独立于刺激环境。为了将动物身上的这些发现与人类头皮电位联系起来，我们调查了声刺激的背景因素，即频谱差异，是否影响神经适应的传播。当人类参与者听随机的音调序列时，脑电被记录下来，这些音调序列的频谱差异(窄与宽)不同。通过基于光谱-时间刺激历史的单次神经适应和随后的恢复建模，研究了适应的传播。在N1分量上，特定频率的神经反应最大，所建的神经适应指数对逐个试验的幅度变化具有很强的预测性。然而，适应的扩展取决于刺激中的频谱变化，从而使具有较大频谱变化的音调序列的适应扩展被扩大。因此，目前的发现揭示了上下文相关的听觉皮质适应，并指出了一种灵活调整的听觉系统，该系统根据声学环境的频谱要求改变其响应特性。
Herrmann B, Henry MJ, Obleser J. Frequency-specific adaptation in human auditory cortex depends on the spectral variance in the acoustic stimulation. J Neurophysiol 109: 2086-2096, 2013. First published January 23, 2013; doi:10.1152/jn.00907.2012.-In auditory cortex, activation and subsequent adaptation is strongest for regions responding best to a stimulated tone frequency and less for regions responding best to other frequencies. Previous attempts to characterize the spread of neural adaptation in humans investigated the auditory cortex N1 component of the event-related potentials. Importantly, however, more recent studies in animals show that neural response properties are not independent of the stimulation context. To link these findings in animals to human scalp potentials, we investigated whether contextual factors of the acoustic stimulation, namely, spectral variance, affect the spread of neural adaptation. Electroencephalograms were recorded while human participants listened to random tone sequences varying in spectral variance (narrow vs. wide). Spread of adaptation was investigated by modeling single-trial neural adaptation and subsequent recovery based on the spectro-temporal stimulation history. Frequency-specific neural responses were largest on the N1 component, and the modeled neural adaptation indices were strongly predictive of trial-by-trial amplitude variations. Yet the spread of adaption varied depending on the spectral variance in the stimulation, such that adaptation spread was broadened for tone sequences with wide spectral variance. Thus the present findings reveal context-dependent auditory cortex adaptation and point toward a flexibly adjusting auditory system that changes its response properties with the spectral requirements of the acoustic environment.