Energy expenditure of adult male rhesus monkeys during the first 30 mo of dietary restriction.
Energy expenditure of adult male rhesus monkeys during the first 30 mo of dietary restriction.
复制标题
成年雄性恒河猴在饮食限制的前 30 个月内的能量消耗。
DOI：
10.1152/ajpendo.1997.272.5.e901
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Kemnitz,JW
中科院分区：
文献类型：
--
作者：
Ramsey,JJ;Roecker,EB;Weindruch,R;Kemnitz,JW
能量消耗，活动，和身体成分进行了测量，在30个成年雄性恒河猴在一项研究中使用的长期目标，确定适度的饮食限制（DR）对衰老的影响。所有动物均饲喂规定的饲料，限制动物的热量摄入量维持在对照动物的约70%。DR 12个月后，限制猴的体脂量比对照组少33%（P = 0.004），而瘦体重差异直到24个月后才出现。在24个月和30个月的评估中，在调整瘦体重差异后，与对照组相比，限制组的夜间能量消耗显著降低（P < 0.01），而早晨、下午和总能量消耗无显著差异（P > 0.05）。在任何时间点，治疗组之间的活性均无显著差异（P > 0.05）。DR导致静息能量消耗的长期减少，这可能有助于这种治疗的可能的延长生命的作用。
Energy expenditure, activity, and body composition were measured in 30 adult male rhesus monkeys used in a study having the long-term goal of determining the effects of moderate dietary restriction (DR) on aging. All animals were fed a defined diet, with the restricted animals maintained at approximately 70% of the caloric intakes of the controls. After 12 mo of DR, body fat mass of restricted monkeys was 33% less than that of controls (P = 0.004), whereas lean body mass differences were not present until after 24 mo. At the 24- and 30-mo assessments, nighttime energy expenditure was significantly reduced (P < 0.01) in the restricted compared with control monkeys after adjustment for lean body mass differences, whereas morning, afternoon, and total energy expenditure were not significantly different (P > 0.05). No significant differences (P > 0.05) in activity were noticed between treatment groups at any time point. DR resulted in a prolonged decrease in resting energy expenditure, which could contribute to the possible life-extending action of this treatment.