Age-dependent glomerulosclerosis and proteinuria occurring in rats of the Milan normotensive strain and not in rats of the Milan hypertensive strain.
Age-dependent glomerulosclerosis and proteinuria occurring in rats of the Milan normotensive strain and not in rats of the Milan hypertensive strain.
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年龄依赖性肾小球硬化和蛋白尿发生在米兰正常血压品系的大鼠中，而不是在米兰高血压品系的大鼠中。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
K. Kühn
中科院分区：
文献类型：
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作者：
A. Brandis;G. Bianchi;E. Reale;U. Helmchen;K. Kühn
通过比较米兰高血压品系（MHS）和米兰正常高血压品系（MNS）大鼠，研究了两品系中度高血压模型大鼠年龄依赖性肾小球硬化和蛋白尿的发展情况。研究了2 ~ 16月龄MHS和MNS大鼠血清肌酐、尿蛋白排泄、肾脏形态学（光镜和电镜）、肾内动脉中膜厚度和肾小球基底膜厚度的形态学测定。血清肌酐在各年龄组MNS和MHS大鼠之间均无差异。MNS大鼠在13至16个月时出现了明显的蛋白尿，并伴有肾小球硬化，约占肾小球硬化的22%。相比之下，MHS大鼠尿蛋白排泄在整个观察期内保持稳定；在13至16个月时，肾小球硬化仅发生在3%的肾小球。由于高血压，MHS大鼠肾内动脉的中膜厚度在2月龄时已明显超过MNS大鼠，在13 ~ 16月龄时在小叶间动脉中膜厚度明显超过MNS大鼠。MHS大鼠肾小球基底膜厚度未超过MNS大鼠。从这些数据我们得出结论，MHS大鼠的肾小球可以防止年龄依赖性肾小球硬化和蛋白尿的发展。最近的实验表明，MHS大鼠的小管肾小球反馈敏感性明显高于MNS大鼠，这也进一步支持了这一结论（41）。
The development of an age-dependent glomerulosclerosis and proteinuria was investigated in two strains of rats in a model of moderate hypertension comparing rats of the Milan Hypertensive Strain (MHS) with rats of the Milan Normotensive Strain (MNS). Serum creatinine, urinary protein excretion, renal morphology (light- and electronmicroscopy) and morphometry of the media thickness of the intrarenal arteries and of the thickness of the glomerular basement membrane were studied in 2- to 16-month-old MHS and MNS rats. Serum creatinine did not differ between MNS and MHS rats in any age group. MNS rats developed a significant proteinuria which coincided with a glomerulosclerosis in about 22% of the glomeruli at 13 to 16 months. In contrast, urinary protein excretion in MHS rats remained stable during the entire observation period; glomerulosclerosis occurred only in 3% of the glomeruli at 13 to 16 months. As a consequence of hypertension media thickness of intrarenal arteries of MHS rats significantly exceeded that of MNS rats, in the interlobular arteries already at 2 months and in the arcuate arteries at 13 to 16 months. In contrast, thickness of the glomerular basement membrane of MHS rats never exceeded that of MNS rats. From these data we conclude, that glomeruli of MHS rats may be protected against the development of an age-dependent glomerulosclerosis and proteinuria. Further support for this conclusion may also be derived from recent experiments showing that the tubuloglomerular feedback sensitivity is significantly higher in MHS than in MNS rats (41).