Bioinformatic analysis of PFN2 dysregulation and its prognostic value in head and neck squamous carcinoma
Bioinformatic analysis of PFN2 dysregulation and its prognostic value in head and neck squamous carcinoma
复制标题
DOI：
10.2217/fon-2017-0348
复制
发表时间：
2018-02-01
期刊：
影响因子：
3.3
通讯作者：
Pan, Jian
中科院分区：
文献类型：
--
作者：
Liu, Jiyuan;Wu, Yunlong;Pan, Jian
目的：本研究旨在探讨PFN 2在头颈部鳞状细胞癌（HNSC）中的表达谱、预后价值及其调控机制。材料和方法：使用基因表达综合数据集、人类蛋白质图谱和癌症基因组图谱-HNSC中的数据进行生物信息学分析。结果：PFN 2在HNSC中表达较正常头颈部组织明显增强。PFN 2高表达独立预测原发性HNSC的总生存率较差（风险比：1.548，95%CI：1.174-2.042; p = 0.002）。14%的HNSC病例有PFN 2扩增。PFN 2 DNA甲基化与其mRNA表达呈负相关（Pearson's r = -0.713）。结论：PFN 2高表达可能是HNSC总生存率低的一个有价值的预测因素。DNA扩增和低甲基化可能是PFN 2调控异常的两种机制。
Aim: This study aimed to identify PFN2 expression profile, its prognostic value and the mechanism of its dysregulation in head and neck squamous cell carcinoma (HNSC). Materials & methods: Bioinformatic analysis was performed using data in the Gene Expression Omnibus Datasets, Human Protein Atlas and The Cancer Genome Atlas-HNSC. Results: PFN2 was upregulated in HNSC than in normal head and neck tissues. High PFN2 expression independently predicted poor overall survival in primary HNSC (hazard ratio: 1.548, 95% CI: 1.174-2.042; p = 0.002). Fourteen percent of HNSC cases had PFN2 amplification. PFN2 DNA methylation was negatively correlated with its mRNA expression (Pearson's r = -0.713). Conclusion: High PFN2 expression might serve as a valuable predictor for poor overall survival of HNSC. DNA amplification and hypomethylation might be two mechanisms of PFN2 dysregulation.